The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
about
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activityZinc transporter 8 (ZnT8) and β cell functionINS-gene mutations: from genetics and beta cell biology to clinical diseaseCarboxypeptidase M in brain and peripheral nervesPreptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretionProinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirusProcessing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.Insulin secretion and insulin-producing tumorsIncreased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A alpha 20 Val --> Asp).Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell.How peptide hormone vesicles are transported to the secretion site for exocytosis.Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin.Insulin-secreting non-islet cells are resistant to autoimmune destruction.Cloning, Transformation and Expression of Proinsulin Gene in Tomato (Lycopersicum esculentum Mill.).Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media.Effects of changes in acid base and calcium concentration on fasting serum insulin, proinsulin, and glucose concentrations.Proteomics analysis of insulin secretory granules.Sorting and processing of secretory proteins.Regulatable production of mature insulin from a hepatocyte cell line: insulin production is up-regulated by cAMP and glucocorticoids, and down-regulated by insulin.Induced and spontaneous mutations at Ser202 of carboxypeptidase E. Effect on enzyme expression, activity, and intracellular routing.Proprotein-processing endoprotease furin decreases regulated secretory pathway-specific proteins in the pancreatic beta cell line MIN6.The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing.Sequence requirements for proinsulin processing at the B-chain/C-peptide junction.Kinetic analysis of the type-1 proinsulin endopeptidase by a monoclonal antibody-based immunoadsorbent assay.Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin IIEndoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell.The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptidesProteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules.Carboxypeptidase E, Identified As a Direct Interactor of Growth Hormone, Is Important for Efficient Secretion of the Hormone.Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.Regulation of carboxypeptidase E. Effect of pH, temperature and Co2+ on kinetic parameters of substrate hydrolysis.Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins.In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process.Influence of emotional-algic stress on the activity of carboxypeptidase H--an enzyme involved in processing rat brain neuropeptides.Reconstitution of adipokinetic hormone biosynthesis in vitro indicates steps in prohormone processing.
P2860
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P2860
The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
description
1987 nî lūn-bûn
@nan
1987 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
The insulin-secretory-granule ...... ement in proinsulin processing
@ast
The insulin-secretory-granule ...... ement in proinsulin processing
@en
The insulin-secretory-granule ...... ement in proinsulin processing
@nl
type
label
The insulin-secretory-granule ...... ement in proinsulin processing
@ast
The insulin-secretory-granule ...... ement in proinsulin processing
@en
The insulin-secretory-granule ...... ement in proinsulin processing
@nl
prefLabel
The insulin-secretory-granule ...... ement in proinsulin processing
@ast
The insulin-secretory-granule ...... ement in proinsulin processing
@en
The insulin-secretory-granule ...... ement in proinsulin processing
@nl
P2860
P3181
P356
P1433
P1476
The insulin-secretory-granule ...... ement in proinsulin processing
@en
P2093
H W Davidson
J C Hutton
P2860
P304
P3181
P356
10.1042/BJ2450575
P407
P577
1987-07-15T00:00:00Z