Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
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The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6INS-gene mutations: from genetics and beta cell biology to clinical diseasePronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemiaInefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis.Molecular insights into insulin action and secretion.Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish menIslet β cell mass in diabetes and how it relates to function, birth, and death.Effect of glucagon-like peptide-1 on beta- and alpha-cell function in isolated islet and whole pancreas transplant recipientsIslet neogenesis: a possible pathway for beta-cell replenishment.Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic ratsHyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humansMechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37).Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.Biophysical alteration of the secretory track in β-cells due to molecular overcrowding: the relevance for diabetes.The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial.Endoplasmic reticulum overcrowding as a mechanism of beta-cell dysfunction in diabetes.Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.β-Cell dysfunction under hyperglycemic stress: a molecular model.Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity.Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Proinsulin and the proinsulin/insulin ratio in overweight and obese children and adolescents: relation to clinical parameters, insulin resistance, and impaired glucose regulation.β-Cell Failure or β-Cell Abuse?
P2860
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P2860
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Increased secretory demand rat ...... n-dependent diabetes mellitus.
@ast
Increased secretory demand rat ...... n-dependent diabetes mellitus.
@en
type
label
Increased secretory demand rat ...... n-dependent diabetes mellitus.
@ast
Increased secretory demand rat ...... n-dependent diabetes mellitus.
@en
prefLabel
Increased secretory demand rat ...... n-dependent diabetes mellitus.
@ast
Increased secretory demand rat ...... n-dependent diabetes mellitus.
@en
P2093
P2860
P356
P1476
Increased secretory demand rat ...... n-dependent diabetes mellitus.
@en
P2093
C J Rhodes
G T Schuppin
P2860
P304
P356
10.1172/JCI117748
P407
P577
1995-03-01T00:00:00Z