Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters
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A competitive inhibitor traps LeuT in an open-to-out conformation.X-ray structures of LeuT in substrate-free outward-open and apo inward-open statesThe interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IVActive sugar transport in health and diseaseMouse SGLT3a generates proton-activated currents but does not transport sugarFunctional characterization of mouse sodium/glucose transporter type 3bUrea transport by nitrogen-regulated tonoplast intrinsic proteins in Arabidopsis.Phlorizin recognition in a C-terminal fragment of SGLT1 studied by tryptophan scanning and affinity labeling.A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter.Forces and dynamics of glucose and inhibitor binding to sodium glucose co-transporter SGLT1 studied by single molecule force spectroscopy.Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.Water pumps.Inhibition of the intestinal sodium-coupled glucose transporter 1 (SGLT1) by extracts and polyphenols from apple reduces postprandial blood glucose levels in mice and humans.Structural selectivity of human SGLT inhibitors.Bridging the gap between structure and kinetics of human SGLT1.Conformational dynamics of hSGLT1 during Na+/glucose cotransportPerturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter.Inhibitors of the gamma-aminobutyric acid transporter 1 (GAT1) do not reveal a channel mode of conductionStructure and function of Na(+)-symporters with inverted repeats.Structural perspectives on secondary active transporters.Effects on conformational states of the rabbit sodium/glucose cotransporter through modulation of polarity and charge at glutamine 457Residue 457 controls sugar binding and transport in the Na(+)/glucose cotransporter.Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.Electrophysiological characterization of the human Na(+)/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function.Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes.Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1.Structure, Function, and Modulation of γ-Aminobutyric Acid Transporter 1 (GAT1) in Neurological Disorders: A Pharmacoinformatic Prospective
P2860
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P2860
Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@ast
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@en
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@nl
type
label
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@ast
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@en
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@nl
prefLabel
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@ast
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@en
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@nl
P2093
P2860
P356
P1476
Common mechanisms of inhibitio ...... l-/GABA (hGAT1) cotransporters
@en
P2093
A Díez-Sampedro
B A Hirayama
E M Wright
P2860
P304
P356
10.1038/SJ.BJP.0704274
P407
P577
2001-10-01T00:00:00Z