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Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

http://www.wikidata.org/entity/Q28364726

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PARticipation in inflammation Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2 Can PRP effectively treat injured tendons?Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1 PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis Loss of prostaglandin E2 release from immortalized urothelial cells obtained from interstitial cystitis patient bladders Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells Modulation of expression of innate immunity markers CXCL5/ENA-78 and CCL20/MIP3alpha by protease-activated receptors (PARs) in human gingival epithelial cells A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury.Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease.NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice.Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium.Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease.Functional protease-activated receptors in the dorsal motor nucleus of the vagus.Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.HGF mediates the anti-inflammatory effects of PRP on injured tendons.Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis.2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice.Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice.Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)Immune networks in animal models of inflammatory bowel disease.Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents.Modulation of visceral pain and inflammation by protease-activated receptors.Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2.Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder.Protease-activated receptor-2 augments experimental crescentic glomerulonephritis Clinical relevance of proteinase activated receptors (pars) in the gut Protease-activated receptors and inflammatory hyperalgesia.Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.Protease-activated receptors: potential therapeutic targets in irritable bowel syndrome?

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P2860

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

http://www.wikidata.org/entity/Q28364726

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Proceedings of the National Academy of Sciences of the United States of America

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Proteinase-activated receptor ...... es in a mouse model of colitis

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A Mencarelli

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B Palazzetti

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P2860

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

Molecular cloning of a potential proteinase activated receptor

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection

Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1

Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease.

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10.1073/PNAS.241377298

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24

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Giuseppe Cirino

Nathalie Vergnolle

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