Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor - Wikidata - wikimedia - TriplyDB

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

http://www.wikidata.org/entity/Q28343653

about

Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP Thrombin receptors and their antagonists: an update on the patent literature Contractile actions of proteinase-activated receptor-derived polypeptides in guinea-pig gastric and lung parenchymal strips: evidence for distinct receptor systems Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo.Evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation.Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for antiangiogenic therapy.Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor beta type I receptor.A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.Protease activated receptors: theme and variations.Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy.Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets Therapeutic potential of protease-activated receptor-1 antagonists.Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer.Protease-activated receptors in the cardiovascular system.Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells.Matrix metalloprotease-1a promotes tumorigenesis and metastasis.Protease-activated receptors in cancer: A systematic review.Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.Why thrombin PAR1 receptors are important to the cardiac surgical patient Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis.Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.Platelet thrombin receptor antagonism and atherothrombosis Vascular PAR-1: activity and antagonism.The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options.Proteinases, Their Extracellular Targets, and Inflammatory Signaling.Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders.Targeting PAR1: Now What?Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling.Discovery of Octahydroindenes as PAR1 Antagonists.Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism.

P2860

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P2860

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

http://www.wikidata.org/entity/Q28343653

description

1999 nî lūn-bûn

@nan

1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1999 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Design, synthesis, and biologi ...... for a tethered-ligand receptor

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Design, synthesis, and biologi ...... for a tethered-ligand receptor

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Design, synthesis, and biologi ...... for a tethered-ligand receptor

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type

label

Design, synthesis, and biologi ...... for a tethered-ligand receptor

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Design, synthesis, and biologi ...... for a tethered-ligand receptor

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Design, synthesis, and biologi ...... for a tethered-ligand receptor

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prefLabel

Design, synthesis, and biologi ...... for a tethered-ligand receptor

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Design, synthesis, and biologi ...... for a tethered-ligand receptor

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Design, synthesis, and biologi ...... for a tethered-ligand receptor

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PNAS.96.22.12257

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Design, synthesis, and biologi ...... for a tethered-ligand receptor

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A J Eckardt

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A L Darrow

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B E Maryanoff

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C E Smith

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C K Derian

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D F McComsey

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D Oksenberg

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H C Zhang

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K B White

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P2860

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

Protease-activated receptor 3 is a second thrombin receptor in humans

Cloning and characterization of human protease-activated receptor 4

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

Molecular cloning of a potential proteinase activated receptor

Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling

A dual thrombin receptor system for platelet activation

Expression of smooth muscle-specific alpha-isoactin in cultured vascular smooth muscle cells: relationship between growth and cytodifferentiation

Structure and function of G protein coupled receptors.

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12257-12262

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96

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12764561

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10535908

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22903

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