Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases
about
Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosidesEffects of various nucleosides on antiviral activity and metabolism of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus types 1 and 2Interaction of Epstein-Barr virus DNA polymerase and 5'-triphosphates of several antiviral nucleoside analogsActivity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegalovirusesComparison of susceptibilities of varicella-zoster virus and herpes simplex viruses to nucleoside analogsActivities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanineAntiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridineStructure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of BrivudineChemotherapeuticsTargeting of an inducible toxic phenotype in animal cellsUnique metabolism of a novel antiviral L-nucleoside analog, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil: a substrate for both thymidine kinase and deoxycytidine kinaseAn Escherichia coli system expressing human deoxyribonucleoside salvage enzymes for evaluation of potential antiproliferative nucleoside analogs.Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.Synthesis and biological effects of 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil.Antiviral activity of 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-5-iodocytosine against human cytomegalovirus in human skin fibroblastsPossible molecular basis for antiviral activity of certain 5-substituted deoxyuridines.Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on proliferation of human fibroblasts, peripheral blood mononuclear cells, and granulocyte-monocyte progenitor cells in vitro.Monitoring HSVtk suicide gene therapy: the role of [(18)F]FHPG membrane transportHuman cytomegalovirus-induced DNA polymerase and its interaction with the triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, -5-iodocytosine, and -5-methylcytosineThymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses.Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2.Drug interactions with zidovudine phosphorylation in vitro.Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity.Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2.Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus.Ganciclovir-resistant cytomegalovirus clinical isolates: mode of resistance to ganciclovir.Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture.Substrate specificity of Epstein-Barr virus thymidine kinase.Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.Retroviral transfer of HSV1-TK gene into human lung cancer cell line.Metabolic fate of [3H]1-beta-D-arabinofuranosyl-5-[(E)-2-bromovinyl]uracil in herpes simplex virus type 1-infected cells.Potent inhibitory effects of the 5'-triphosphates of (E)-5-(2-bromovinyl)-2'-deoxyuridine and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on DNA polymerase gamma.Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors.Antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against thymidine kinase negative strains of varicella-zoster virus.Effect of acyclovir and presence of cellular and viral thymidine kinase activity in herpes simplex virus infected cells. Brief report.Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
P2860
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P2860
Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases
description
1981 nî lūn-bûn
@nan
1981 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1981 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1981年の論文
@ja
1981年論文
@yue
1981年論文
@zh-hant
1981年論文
@zh-hk
1981年論文
@zh-mo
1981年論文
@zh-tw
1981年论文
@wuu
name
Differential activity of poten ...... man cellular thymidine kinases
@ast
Differential activity of poten ...... man cellular thymidine kinases
@en
Differential activity of poten ...... man cellular thymidine kinases
@nl
type
label
Differential activity of poten ...... man cellular thymidine kinases
@ast
Differential activity of poten ...... man cellular thymidine kinases
@en
Differential activity of poten ...... man cellular thymidine kinases
@nl
prefLabel
Differential activity of poten ...... man cellular thymidine kinases
@ast
Differential activity of poten ...... man cellular thymidine kinases
@en
Differential activity of poten ...... man cellular thymidine kinases
@nl
P2093
P2860
P356
P1476
Differential activity of poten ...... man cellular thymidine kinases
@en
P2093
P2860
P356
10.1128/AAC.20.3.420
P407
P577
1981-09-01T00:00:00Z