Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
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Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitorsAntiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in manAntiviral L-nucleosides specific for hepatitis B virus infectionIdentification of BMS-200475 as a potent and selective inhibitor of hepatitis B virusInhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracilAssessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication.Cell-based and animal models for hepatitis B and C viruses.A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseaseDifferential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells.Inherited mitochondrial DNA depletion.Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors.In vitro mitochondrial toxicity of metacavir, a new nucleoside reverse transcriptase inhibitor for treatment of hepatitis B virus.Anti-HBV specific beta-L-2'-deoxynucleosides.Nonclinical safety profile of telbivudine, a novel potent antiviral agent for treatment of hepatitis BEvaluation of mitochondrial toxicity in Marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis B Virus.Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders.Imaging virus-associated cancer.Role of metabolism in drug-induced idiosyncratic hepatotoxicity.Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B: results of an open, controlled trial.Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors.Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.Differential effects of the incorporation of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) on the binding of the transcription factors, AP-1 and TFIID, to their cognate target DNA sequences.Intracellular nucleotides of (-)-2',3'-deoxy-3'-thiacytidine in peripheral blood mononuclear cells of a patient infected with human immunodeficiency virus.Antiviral activities of MCC-478, a novel and specific inhibitor of hepatitis B virus.Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity.Thymidine phosphorylase deficiency causes MNGIE: an autosomal recessive mitochondrial disorder.Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro.New therapies for chronic hepatitis B.Entecavir for treatment of hepatitis B virus displays no in vitro mitochondrial toxicity or DNA polymerase gamma inhibition.Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication.Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases.Current status of anti-HBV chemotherapy.Role of mitochondria in silica-induced apoptosis of alveolar macrophages: inhibition of apoptosis by rhodamine 6G and N-acetyl-L-cysteine.Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.Anti-DNA Virus Agents
P2860
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P2860
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Cellular and molecular events ...... douracil in human liver cells.
@en
type
label
Cellular and molecular events ...... douracil in human liver cells.
@en
prefLabel
Cellular and molecular events ...... douracil in human liver cells.
@en
P2093
P2860
P356
P1476
Cellular and molecular events ...... douracil in human liver cells.
@en
P2093
P2860
P304
P356
10.1172/JCI117698
P407
P577
1995-02-01T00:00:00Z