A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
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K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanismSelective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptaseStructural basis of HIV-1 resistance to AZT by excisionStable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnetMg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance.Impact of human immunodeficiency virus type-1 sequence diversity on antiretroviral therapy outcomesCurrent perspectives on HIV-1 antiretroviral drug resistanceThe choreography of HIV-1 proteolytic processing and virion assemblyGeneral Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide AnaloguesStructural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptaseCrystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceComplexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradationHIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanismAmino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profilesAlkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistanceShould we include connection domain mutations of HIV-1 reverse transcriptase in HIV resistance testingN348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistanceHIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selectionZidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptaseNovel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-templateAllosteric regulation of HIV-1 reverse transcriptase by ATP for nucleotide selection.Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance.Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations.The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69.Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excisionYADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.Genotypic testing for human immunodeficiency virus type 1 drug resistance.Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis.N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms
P2860
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P2860
A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@ast
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@en
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@nl
type
label
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@ast
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@en
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@nl
prefLabel
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@ast
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@en
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@nl
P2093
P1433
P1476
A mechanism of AZT resistance: ...... nt HIV-1 reverse transcriptase
@en
P2093
P407
P577
1999-07-01T00:00:00Z