IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1
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Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosisMembers of the DAN family are BMP antagonists that form highly stable noncovalent dimersDNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancersChordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implicationsDiscovery of genes related to diabetic nephropathy in various animal models by current techniques.Gremlin-2 is a BMP antagonist that is regulated by the circadian clockUrine matrix metalloproteinase-7 and risk of kidney disease progression and mortality in type 2 diabetes.Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma.In vivo delivery of Gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7.A GREM1 gene variant associates with diabetic nephropathy.Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease.Tubular overexpression of gremlin induces renal damage susceptibility in mice.Evaluation of gremlin 1 (GREM1) as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type 2 diabetes mellitus.Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection.High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly.Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathwayHaemodynamics in microvascular complications in type 1 diabetes.Ontogeny of the kidney and renal developmental markers in the rhesus monkey (Macaca mulatta)Osteogenic regulation of vascular calcification: an early perspective.Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosisIncisional hernia recurrence through genomic profiling: a pilot study.IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis.Allelic depletion of grem1 attenuates diabetic kidney disease.Role of gremlin in the lung: development and disease.The genetics of diabetic nephropathy.Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.Targeting cellular drivers and counter-regulators of hyperglycaemia- and transforming growth factor-β1-associated profibrotic responses in diabetic kidney disease.Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension.Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes.Gremlin gene expression in bovine retinal pericytes exposed to elevated glucoseGremlin activates the Smad pathway linked to epithelial mesenchymal transdifferentiation in cultured tubular epithelial cells.Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice.Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway.Gremlin and renal diseases: ready to jump the fence to clinical utility?Tubular overexpression of Gremlin in transgenic mice aggravates renal damage in diabetic nephropathy.Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.
P2860
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P2860
IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1
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2000 nî lūn-bûn
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2000年の論文
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
@ast
IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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P2093
P356
P1476
IHG-2, a mesangial cell gene i ...... ansforming growth factor-beta1
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P2093
H S Mackenzie
M Clarkson
P304
P356
10.1074/JBC.275.14.9901
P407
P577
2000-04-07T00:00:00Z