Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes
about
Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytesSummary of information on human CYP enzymes: human P450 metabolism data.Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Targeting the pregnane X receptor in liver injury.Role of metabolism in drug-induced idiosyncratic hepatotoxicity.Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates.Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes.Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinicalHepatocyte isolation from resected benign tissues: Results of a 5-year experience.Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format.Competency of different cell models to predict human hepatotoxic drugs.Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.Gene expression analysis of troglitazone reveals its impact on multiple pathways in cell culture: a case for in vitro platforms combined with gene expression analysis for early (idiosyncratic) toxicity screening.Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects.A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.Automated triplexed hepatocyte-based viability and CYP1A and -3A induction assays.Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes.Tissue collection, transport and isolation procedures required to optimize human hepatocyte isolation from waste liver surgical resections. A multilaboratory study.
P2860
Q28477796-8B116277-9613-495A-A09F-42051D0475DDQ32103802-54C8ED36-A239-4B1C-A3AF-26D849788F54Q34235817-839DFFE8-30FE-4BC9-A4EC-10112B15A87DQ35015993-6A1904C6-48C3-4140-9316-C160E24B5517Q35057368-BC13B377-FB51-401A-9573-7BCCAB948AADQ36179528-BDE733FF-82DA-4BDC-B055-C81C6D6E6BC2Q36544962-C33B35CB-EBFD-42CC-90E0-E0393A7D139BQ36871062-A23FFF20-AD66-456B-B159-F161C7D9D2B9Q37237446-CFC7AC19-EC3A-4F90-B694-643D88741CBEQ37284500-4A46937B-AE30-4DF4-AEE2-8A3A278E8E59Q37480700-859B08A8-B3DE-4BBA-B5E7-3C3AA408C135Q38258251-5F2FEC58-D2FA-43EE-87EA-30B3E33F9957Q39920320-33BD066D-AEF9-4769-B27F-89DDCDA18C9BQ40295334-C93F508E-8239-46E7-B349-004FE0062BF7Q43613500-DC334EAE-615E-48E2-8183-35295894F21FQ44305000-4F444FAA-B85B-4A6C-82DE-D7BD870C3523Q44881276-2876F982-4B25-41DF-99B4-85B78BBE459EQ45930411-5C25384A-8DFC-4B9B-9EC2-0E3BFDCC703CQ46402118-2E5A61AD-391E-4ECB-AD6E-1136B8BD9C34Q51637422-42FCA481-A043-4DD7-89CF-ED607B2FCBA2
P2860
Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@ast
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@en
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@nl
type
label
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@ast
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@en
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@nl
prefLabel
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@ast
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@en
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@nl
P2093
P3181
P356
P1433
P1476
Effect of troglitazone on cyto ...... s of human and rat hepatocytes
@en
P2093
E L LeCluyse
G Hamilton
P2860
P304
P3181
P356
10.1080/004982500237668
P407
P577
2000-03-01T00:00:00Z