Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis
about
Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthasesIdentification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabHEffects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesisX-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by ThiolactomycinIn vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesisACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteriaMycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosisSignature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosisIdentification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatisSynthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitorsGenetics and pulmonary medicine. 5. Genetics of drug resistant tuberculosisSlow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.Response of Bacillus subtilis to cerulenin and acquisition of resistance.A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylationStructure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabGNew approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition.Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis.The membrane as a target for controlling hypervirulent Clostridium difficile infections.Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesisChemotherapeutic interventions against tuberculosisRecent advances in the chemistry and biology of naturally occurring antibiotics.2D-QSAR model development and analysis on variant groups of anti-tuberculosis drugsIntrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems.Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strainCharacterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene.Role of long-chain acyl-CoAs in the regulation of mycolic acid biosynthesis in mycobacteria.
P2860
Q21562402-3E4DE3B7-B944-4F7D-8FAD-19D70EF686A5Q21562445-69541E05-1754-4ACF-9CF3-97F8DA27443BQ24538909-88EE0DF5-09AA-43D2-9A19-51781B31D5D5Q24550666-66AF0E4B-1F8A-4E08-9F5C-7E22126C5FD8Q27640802-5815BDD9-8C6D-4879-AE11-562554255128Q27656454-B4A84743-EF1B-479E-989A-08B8C3705C5FQ28360724-DFA32BA3-DBA3-4199-A094-727F7174BFB3Q28486788-F647FD08-E18E-46E2-A031-309B697D5FEBQ28487484-4E36C60C-52DB-4488-A004-0CC995C3C020Q28487562-BBBD48C7-721C-45F5-928E-414193D9E857Q28552712-D9FDBDEC-DF83-4F59-84CC-7388EE0944BEQ30844885-EC1B3557-6F07-40D3-9006-01396CB7C536Q33292548-200A5D1C-0A2A-4671-8E57-1552CB05F070Q33630442-0BABF4FF-9236-4FA5-BAF8-DB71257335E8Q33673527-64AE1123-EA90-45FE-9F96-9A7EA1E54DD7Q33917913-0C1CAB16-7A7E-4588-9954-B71E7E01C467Q33996150-9F24A539-710D-4FFF-A872-50A0B1742ADAQ34107208-0DBE0CBC-984C-4149-B61E-2713C14EEC82Q34306954-E9053C4E-E53F-41DD-BDB9-4C07294C3E25Q34575278-EA7A25F6-3129-4314-853B-37E88FE3BE72Q34619663-2F189211-B063-468B-A893-233397CF56D9Q35879195-AF8C9F04-6F0E-4427-8C0F-253D4F587FBCQ36057012-ED71ABF0-3F85-4436-A9B4-755FC1D91604Q36101770-FC1911D6-A67F-466A-8063-F25457259FE0Q36364079-9A3286FA-84A4-4FF3-BF21-35A972A4B232Q36963920-2F6FA7B3-3E84-4A8C-9F0E-6834E08C4152Q37030173-BCD09A38-A9F0-44DB-ADC7-66429880B667Q37038925-AFC80199-EBC0-4264-A542-4487E10C75F1Q37148764-F6E07D79-78E4-49B9-AB6E-DBCC621899E8Q37313939-FA0264EA-F9E8-4DB4-A7AA-9909CC38A263Q38450310-4BE1A06B-D0BE-46D3-8D18-E5A6A11C2D04Q39556735-2C0AFD8C-77F4-4B8A-9E62-966D40CC4314Q39614772-ABC55A50-07CA-45C6-B000-9A05835DE1AEQ39648923-50E297AE-D337-4D28-BE4B-632B9BF6C1D2Q39661161-69A5A3AE-094F-4105-AF8C-5AD7187F31ABQ40909374-77789D83-6757-4802-A80D-C5FDBC3202DCQ41225370-6480DFCA-3695-4012-961E-101D78C0179B
P2860
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@ast
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@en
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@nl
type
label
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@ast
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@en
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@nl
prefLabel
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@ast
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@en
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@nl
P2093
P2860
P3181
P1476
Antimycobacterial action of th ...... cid and mycolic acid synthesis
@en
P2093
A M Cooper
J W Armour
P J Brennan
R A Slayden
P2860
P304
P3181
P407
P577
1996-12-01T00:00:00Z