Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain - Wikidata - wikimedia - TriplyDB

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

http://www.wikidata.org/entity/Q28386823

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Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012 Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate Comparison of [(11)C]TZ1964B and [(18)F]MNI659 for PET imaging brain PDE10A in nonhuman primates Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [¹¹C]MP-10 PET rodent imaging study with ex vivo confirmation.Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis.Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.Development of a series of novel carbon-11 labeled PDE10A inhibitors.Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter.Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.PET radiopharmaceuticals for probing enzymes in the brain Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET.Phosphodiesterase 10A inhibitors: a 2009 - 2012 patent update.Investigational drugs for the management of Huntington's disease: are we there yet?Radiosynthesis and biological evaluation of the new PDE10A radioligand [18 F]AQ28A.Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A.Evaluation of a novel PDE10A PET radioligand, [(11) C]T-773, in nonhuman primates: brain and whole body PET and brain autoradiography.Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging.In vivo characterization of two 18F-labeled PDE10A PET radioligands in nonhuman primate brains.Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193.

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P2860

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

http://www.wikidata.org/entity/Q28386823

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2011 nî lūn-bûn

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J.BMC.2011.01.032

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Bioorganic & Medicinal Chemistry

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Dexing Zeng

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Jinbin Xu

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Jinda Fan

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Joel S Perlmutter

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Prashanth K Padakanti

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Robert H Mach

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Shihong Li

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P2860

Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum

Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia

Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation

Advances in the understanding of early Huntington's disease using the functional imaging techniques of PET and SPET.

Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase.

Genes, dopamine and cortical signal-to-noise ratio in schizophrenia.

Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.

Circuits and circuit disorders of the basal ganglia.

Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia.

Does an imbalance between the dorsal and ventral striatopallidal systems play a role in Tourette's syndrome? A neuronal circuit approach.

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Kooresh I. Shoghi

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2011-01-22T00:00:00Z

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49830761

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