Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase.
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Structural insight into substrate specificity of phosphodiesterase 10Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMPPhosphodiesterases as therapeutic targets for Alzheimer's disease.Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawalPhosphodiesterase 10A regulates alcohol and saccharin self-administration in ratsRadiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brainInhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical StimulationRadiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primateCross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor TraffickingPhosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in StriatumPDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathwaysPhosphodiesterase 10A inhibitor MP-10 effects in primates: comparison with risperidone and mechanistic implicationsDifferential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organsCellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesteraseStress history increases alcohol intake in relapse: relation to phosphodiesterase 10A.Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodelingUbiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activityDiscovery of novel PDE10 inhibitors by a robust homogeneous screening assay.Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.Anti-spasmogenic activity of isoenzyme-selective phosphodiesterase inhibitors in guinea-pig trachealis.Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.A survey for novel imprinted genes in the mouse placenta by mRNA-seqFacilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.Activation of PDE10 and PDE11 phosphodiesterases.Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.Genetic association of cyclic AMP signaling genes with bipolar disorder.PET radiopharmaceuticals for probing enzymes in the brainβ-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKGNovel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder.Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.Emerging targets for addiction neuropharmacology: From mechanisms to therapeuticsPharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM-042 [(E)-4-(2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-6-(pyrrolidin-1-yl)pyrimidin-4-yl)morpholine] in rats: potPatented PDE10A inhibitors: novel compounds since 2007.Clinical and molecular genetics of the phosphodiesterases (PDEs).Phosphodiesterase inhibitors in clinical urology.
P2860
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P2860
Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Isolation and characterization ...... nucleotide phosphodiesterase.
@ast
Isolation and characterization ...... nucleotide phosphodiesterase.
@en
type
label
Isolation and characterization ...... nucleotide phosphodiesterase.
@ast
Isolation and characterization ...... nucleotide phosphodiesterase.
@en
prefLabel
Isolation and characterization ...... nucleotide phosphodiesterase.
@ast
Isolation and characterization ...... nucleotide phosphodiesterase.
@en
P2093
P1433
P1476
Isolation and characterization ...... nucleotide phosphodiesterase.
@en
P2093
P304
P356
10.1016/S0378-1119(99)00171-7
P407
P577
1999-06-01T00:00:00Z