PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy
about
Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancerInvestigational inhibitors of PTP4A3 phosphatase as antineoplastic agents.Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics.Aberrant RNA splicing and mutations in spliceosome complex in acute myeloid leukemia.Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator.Phosphatase of regenerating liver: a novel target for cancer therapy.Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD-negative acute myeloid leukemia.The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemiaOncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma.Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis.Molecular mechanisms of the PRL phosphatases.FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia.Allogeneic stem cell transplantation and targeted therapy for FLT3/ITD+ acute myeloid leukemia: an update.Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies.The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells.Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults.Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia.Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions.Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance.Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration.A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase.Resistance to FLT3 inhibitors in acute myeloid leukemia: Molecular mechanisms and resensitizing strategies
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P2860
PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@ast
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@en
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@nl
type
label
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@ast
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@en
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@nl
prefLabel
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@ast
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@en
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@nl
P2093
P2860
P3181
P1433
P1476
PRL-3, a metastasis associated ...... implicated in anti-AML therapy
@en
P2093
Cheng Peow Bobby Tan
Chien-Shing Chen
Chonglei Bi
Daniel H Albert
Jianbiao Zhou
Kian-Ghee Tay
Lip-Lee Cheong
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0019798
P407
P577
2011-05-12T00:00:00Z