Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6 - Wikidata - wikimedia - TriplyDB

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

http://www.wikidata.org/entity/Q28397050

about

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage Autoregulation of Parkin activity through its ubiquitin-like domain The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling Histone deacetylase 6 interacts with the microtubule-associated protein tau USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1 Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection Parkin Regulation and Neurodegenerative Disorders Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity RBR E3 ubiquitin ligases: new structures, new insights, new questions Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?The role of autophagy in Parkinson's disease Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition UEV-1 is an ubiquitin-conjugating enzyme variant that regulates glutamate receptor trafficking in C. elegans neurons HDAC6 regulates mitochondrial transport in hippocampal neurons 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1 Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins Aggresome formation and neurodegenerative diseases: therapeutic implications Selective autophagy mediated by autophagic adapter proteins Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope The ubiquitin-proteasome system in spongiform degenerative disorders BAG-6 is essential for selective elimination of defective proteasomal substrates Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans.Protein misfolding specifies recruitment to cytoplasmic inclusion bodies Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63 Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.Autophagy and the ubiquitin-proteasome system in cardiac dysfunction.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Parkin-mediated ubiquitin signalling in aggresome formation and autophagy.

P2860

Q24304102-0EE4E82C-5636-4E6A-97DF-597817069C83 Q24307382-E5AB067E-FE3F-48F7-B438-918C3D5A08C7 Q24307589-1DB1B0E3-61B3-4E36-9239-11CD52DFA41B Q24311582-DA61DA56-6AED-4B67-99D1-A41E20A7FFAE Q24311700-50E48163-A19B-49D3-B1EE-9493FCBCB13C Q24313304-405C17DB-F0F8-4EE4-AE29-A0E96EE50A18 Q24315060-ABCF2894-B9C7-46D6-8F78-6743CBC45ACB Q24316142-F54DED5C-BA15-47FD-AE3E-E1AF842A2DBD Q24319839-E8A6B6AF-F5C1-4BC5-ACCC-8676AFFF1904 Q24338612-3E5536E4-0586-466F-9B34-D5E9ADD3D601 Q24608960-F157E90B-8579-43FD-B0E0-14E47D9E31C1 Q24650675-32F2F91E-A42E-407E-B390-B570BA7E5957 Q26770443-D0B13F3C-1F8B-457F-A02C-3EC14D5E00E3 Q26799306-9609A0F4-0AB1-4579-92DB-F8EF9E3E0486 Q26828565-139313E5-BEA5-415B-8316-A4473F8E282B Q27001551-6DD0B42A-AA82-4D0E-938C-7C24EA30FFCE Q27015801-3DCE15E1-F914-4F0E-AA7D-78AACDFE1AC0 Q27023788-F625AEB2-EF38-4D5E-AA9D-3254CD6860E2 Q27308731-246013DD-460D-4EE7-AF89-D86B4C6F44F7 Q27314985-220A0DAB-7CC0-40DF-80D4-3978B6B0885C Q27315936-9F474068-CC32-46A9-B9B8-F041BDF2A83E Q27326879-9676E126-D15D-4F56-9295-067B30074958 Q27930016-A8FFF516-89A7-49C8-9C56-E45FD292E49B Q28258696-3C9AC705-8695-4865-A07D-82751BC6B96A Q28263518-565AFD5D-B4F2-4F32-8129-CE46792D5380 Q28265926-A8F8679C-D4E1-4125-8FC8-EE640D3FC10C Q28301940-D3B74A6F-1F23-4178-80DA-93F49F464A9F Q28386148-5FCC867F-A1F3-4520-8751-8F0E6E25489A Q28386906-91993444-6E44-471B-A462-D0064046378C Q28505838-62F8CD57-95CD-4BA4-B579-ECB3E5EB41C3 Q29615625-A2AA1B10-0F8A-44F6-ACBF-74BFAC865E7A Q30515046-6BB04C4C-1024-4FD7-97DE-953D225DB86E Q30826780-98B33974-85E5-4535-86A6-925E5121B62B Q33385971-0D3842A9-BC69-44C3-9019-6F15C1F119A1 Q33643287-3711BD3F-F3B7-4395-A043-6E20579BD8F8 Q33669403-56C78DFC-4A69-4645-AC94-7A0DA7ADACF9 Q33679929-18546206-7B1F-4C0D-A75D-B29C47831508 Q33733547-1A56F568-92BE-455B-96C6-BAB897972B3F Q33755817-45E22A7D-533D-4799-9B4B-A251FEDDD40E Q33757729-BA5B2C43-6DBC-4ECB-A675-EF838D4562F6

P2860

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

http://www.wikidata.org/entity/Q28397050

description

2007 nî lūn-bûn

@nan

2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@ast

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@en

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@nl

type

label

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@ast

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@en

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@nl

prefLabel

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@ast

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@en

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@nl

P1433

Q28397050-73B69AD0-028C-48E2-9231-936E4A865352

P1476

Q28397050-5CB454BA-D4A3-45A3-896B-139E633602FD

P2093

Q28397050-270CE762-D0D1-4905-8DF8-B12DE76B92AC

Q28397050-272D2BFA-107A-4825-B81D-B2D9BA36CE6F

Q28397050-9B3ED269-7119-43B8-B8EB-E99CEF29E128

Q28397050-C7507943-3B1F-4D43-9638-0366D249F482

Q28397050-FAEBA78B-7F46-4E67-BF1E-044DBE4AD944

P2860

Q28397050-0A9B4B39-17AA-4EF2-8C64-AB04EE69D9D6

Q28397050-10F03BE6-44A6-456D-8A88-8D6CE71AE184

Q28397050-12A3755F-5A76-42AC-9A50-845804A06BAC

Q28397050-1839E924-61ED-4A51-A76F-0E59FB3CC2EE

Q28397050-20AF53F3-C7A4-4973-BD2E-50868AA103CB

Q28397050-20E395A4-9359-4854-ADAF-C0BB09C2372C

Q28397050-39BF6E26-2ADD-4E84-9C3F-B1DA96981578

Q28397050-3BD75AFB-F2AB-4386-A800-10879F3FA450

Q28397050-3E5DB9E7-38F4-4EB3-9574-7081FF8D40CF

Q28397050-3F569217-B108-4F17-8103-F623F7CEBC19

P304

Q28397050-2BBEC40F-4BF4-4952-BBE4-695ADCC59B8C

P31

Q28397050-E6114747-9698-458E-A13B-689CEDA7EB09

P3181

Q28397050-AF8B63CE-3737-481D-8213-38A65FE00CC6

P356

Q28397050-05D7C786-3A75-4FA8-98DB-A4BCA343D311

P407

Q28397050-888735A0-9CED-413B-9BA4-36D513E1DE25

P433

Q28397050-4C3BFC2E-E627-4B39-8411-6BB50C869DA4

P478

Q28397050-A2C37D34-9AE8-4247-A265-B83D2EBA40C4

P50

Q28397050-1D0257B1-F291-418B-ABBB-2C0392FFD354

Q28397050-BF3D540F-C21A-4B7E-87EF-ECDD162184F9

P577

Q28397050-228DBB13-9E77-4D94-9340-8529F7B53DA5

P5875

Q28397050-92B5673D-D44D-4862-AB98-8DCD304D8A0D

P698

Q28397050-ABCBE2EF-765E-4B30-87D4-BE66A38FD777

P921

Q28397050-E75A9E0D-F0E9-4B71-ABEE-12D0082B78BC

P932

Q28397050-32D44DED-CEA5-46EE-B66F-5A156C85A50C

P3181

P356

P1433

Journal of Cell Biology

P1476

Parkin-mediated K63-linked pol ...... ggresomes via binding to HDAC6

@en

P2093

Francisco A Perez

http://www.w3.org/2001/XMLSchema#string

Jue Chen

http://www.w3.org/2001/XMLSchema#string

Lian Li

http://www.w3.org/2001/XMLSchema#string

Maksim V Chudaev

http://www.w3.org/2001/XMLSchema#string

Richard D Palmiter

http://www.w3.org/2001/XMLSchema#string

P2860

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)

Induction of metallothionein l by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation

P304

1025-38

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4923325

http://www.w3.org/2001/XMLSchema#string

P356

10.1083/JCB.200611128

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

178

http://www.w3.org/2001/XMLSchema#string

P50

P577

2007-09-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

238319681

http://www.w3.org/2001/XMLSchema#string

P698

17846173

http://www.w3.org/2001/XMLSchema#string

P921

P932

2064625

http://www.w3.org/2001/XMLSchema#string