The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure - Wikidata - wikimedia - TriplyDB

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

http://www.wikidata.org/entity/Q28473586

about

A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Implication of posttranslational histone modifications in nucleotide excision repair Epigenetics and the control of the collecting duct epithelial sodium channel Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.Histone H3.3 maintains genome integrity during mammalian development The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle Quantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma brucei Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis Epigenetic modifications and human disease Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.Effects of RNAi-mediated knockdown of histone methyltransferases on the sex-specific mRNA expression of Imp in the silkworm Bombyx mori.siRNA-mediated methylation of Arabidopsis telomeres 2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells.LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Discovering cooperative relationships of chromatin modifications in human T cells based on a proposed closeness measure Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Sex-specific dynamics of global chromatin changes in fetal mouse germ cells Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis.Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma Epigenetic heredity of human height.Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats AF10 plays a key role in the survival of uncommitted hematopoietic cells.Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.DOT1L regulates dystrophin expression and is critical for cardiac function.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis.

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P2860

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

http://www.wikidata.org/entity/Q28473586

description

2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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The histone H3K79 methyltransf ...... and heterochromatin structure

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JOURNAL.PGEN.1000190

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The histone H3K79 methyltransf ...... and heterochromatin structure

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Audesh Bhat

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Brendan Jones

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En Li

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Gretchen A Baltus

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Hong Lei

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Hui Su

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Huili Zhai

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Jeffrey Bajko

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Reginald Valdez

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Sarah Hevi

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P2860

Translating the Histone Code

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

Chromatin modifications and their function

Role for the silencing protein Dot1 in meiotic checkpoint control.

hDOT1L links histone methylation to leukemogenesis.

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.

The first molecular details of ALT in human tumor cells

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e1000190

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10.1371/JOURNAL.PGEN.1000190

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