A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs
about
Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimizationMaking the most of clinical data: reviewing the role of pharmacokinetic-pharmacodynamic models of anti-malarial drugsLinking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.Plasmodium vivax Controlled Human Malaria Infection - Progress and ProspectsExternal quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillanceCharacterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy ModelingInitiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection.Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulationEmergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reportsEvaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injectionDevelopment of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines.Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection.Evaluating the pharmacodynamic effect of antimalarial drugs in clinical trials by quantitative PCRModelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance.Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection.Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infectionReduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ ProductionSafety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria TransmissionPlasmodium vivax but Not Plasmodium falciparum Blood-Stage Infection in Humans Is Associated with the Expansion of a CD8+ T Cell Population with Cytotoxic Potential.Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria InfectionPiperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia.Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion-451840 in an induced blood stage malaria study in healthy subjects.Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers.Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite.A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study.Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection.Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium falciparum Malaria.Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct.Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study.Controlled human blood stage malaria infection: current status and potential applications.Novel approaches in antimalarial drug discovery.The emerging threat of artemisinin resistance in malaria: focus on artemether-lumefantrine.Comparison of statistical models to estimate parasite growth rate in the induced blood stage malaria model.Dichotomous miR expression and immune responses following primary blood-stage malaria.Low-level Plasmodium falciparum blood-stage infection causes dendritic cell apoptosis and dysfunction in healthy volunteers.Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana.Controlled human malaria infection.
P2860
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P2860
A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@ast
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@en
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@nl
type
label
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@ast
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@en
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@nl
prefLabel
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@ast
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@en
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@nl
P2093
P2860
P3181
P1433
P1476
A pilot randomised trial of in ...... cacy of new antimalarial drugs
@en
P2093
Andrew J Humberstone
Chris Peatey
Cornelius Hermsen
Jörg Möhrle
Katharine R Trenholme
Louise Marquart
Nanette Douglas
Peter O'Rourke
Rebecca Rockett
Silvana Sekuloski
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0021914
P407
P577
2011-08-22T00:00:00Z