about
Spiroindolones, a potent compound class for the treatment of malariaDrug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drugThe malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugsClinically Available Medicines Demonstrating Anti-Toxoplasma ActivityNext-generation antimicrobials: from chemical biology to first-in-class drugsGlobal phenotypic screening for antimalarialsOpen Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesRecent advances in malaria drug discoveryUsing genetic methods to define the targets of compounds with antimalarial activityChemical biology approaches for the study of apicomplexan parasitesEnvironmental constraints guide migration of malaria parasites during transmissionStructure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate PotentialP6981, An Arylstibonic Acid, Is a Novel Low Nanomolar Inhibitor of cAMP Response Element-Binding Protein Binding to DNAMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetAntimalarial drug discovery - approaches and progress towards new medicines.Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondAnalogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivoDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsMutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone AntimalarialsIdentification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasitesImaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryMapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leadsGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparumIn silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discoverySmall molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5Muddled mechanisms: recent progress towards antimalarial target identificationHigh-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonaseChEMBL: a large-scale bioactivity database for drug discoveryBiochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetaseThe Mycobacterium tuberculosis drugome and its polypharmacological implicationsPhenotypic screens, chemical genomics, and antimalarial lead discoveryA pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugsThe next opportunity in anti-malaria drug discovery: the liver stageIntegrated dataset of screening hits against multiple neglected disease pathogensP. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-actionIdentification of new antileishmanial leads from hits obtained by high-throughput screeningAgrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas diseaseHigh content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discoveryThe open access malaria box: a drug discovery catalyst for neglected diseasesA new in vivo screening paradigm to accelerate antimalarial drug discovery
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Chemical genetics of Plasmodium falciparum
@ast
Chemical genetics of Plasmodium falciparum
@en
type
label
Chemical genetics of Plasmodium falciparum
@ast
Chemical genetics of Plasmodium falciparum
@en
prefLabel
Chemical genetics of Plasmodium falciparum
@ast
Chemical genetics of Plasmodium falciparum
@en
P2093
P2860
P50
P3181
P356
P1433
P1476
Chemical genetics of Plasmodium falciparum
@en
P2093
Abhai K Tripathi
David C Smithson
David J Sullivan
Elizabeth R Sharlow
Emily B Wilson
Fangyi Zhu
Farah El Mazouni
Ian Bathurst
Isaac Forquer
Iñigo Angulo-Barturen
P2860
P2888
P304
P3181
P356
10.1038/NATURE09099
P407
P577
2010-05-01T00:00:00Z
P5875
P6179
1042393051