Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs
about
Kinases as druggable targets in trypanosomatid protozoan parasitesDesign and Synthesis of Inhibitors of Plasmodium falciparumN -Myristoyltransferase, A Promising Target for Antimalarial Drug DiscoveryDiscovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N -MyristoyltransferaseValidation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approachDiverse modes of binding in structures ofLeishmania majorN-myristoyltransferase with selective inhibitorsUsing a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotesGlobal Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma bruceiAcylation in trypanosomatids: an essential process and potential drug targetAn improved method and cost effective strategy for soluble expression and purification of human N-myristoyltransferase 1 in E. coli.Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.Integrated machine learning, molecular docking and 3D-QSAR based approach for identification of potential inhibitors of trypanosomal N-myristoyltransferase.In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferaseN-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.From crystal to compound: structure-based antimalarial drug discovery.Pattern recognition techniques applied to the study of leishmanial glyceraldehyde-3-phosphate dehydrogenase inhibition.Post-translational protein modifications in malaria parasites.Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.Pharmacological Inhibition of Protein Lipidation.N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells.Chemotherapy of leishmaniasis: present challenges.Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.Recent advances in the discovery of N-myristoyltransferase inhibitors.New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness.Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.The N-myristoylome of Trypanosoma cruzi.Multiple chemical scaffolds inhibit a promising Leishmania drug target.Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.Genetically Validated Drug Targets in Leishmania; Current Knowledge and Future Prospects.Identification of electronic and structural descriptors of adenosine analogues related to inhibition of leishmanial glyceraldehyde-3-phosphate dehydrogenase.Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
P2860
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P2860
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Selective inhibitors of protoz ...... e medicinal chemistry programs
@ast
Selective inhibitors of protoz ...... e medicinal chemistry programs
@en
Selective inhibitors of protoz ...... e medicinal chemistry programs
@nl
type
label
Selective inhibitors of protoz ...... e medicinal chemistry programs
@ast
Selective inhibitors of protoz ...... e medicinal chemistry programs
@en
Selective inhibitors of protoz ...... e medicinal chemistry programs
@nl
prefLabel
Selective inhibitors of protoz ...... e medicinal chemistry programs
@ast
Selective inhibitors of protoz ...... e medicinal chemistry programs
@en
Selective inhibitors of protoz ...... e medicinal chemistry programs
@nl
P2093
P2860
P50
P3181
P1476
Selective inhibitors of protoz ...... e medicinal chemistry programs
@en
P2093
Deborah F Smith
Gareth P Williams
James A Brannigan
James E Mills
Robin J Leatherbarrow
Tanya Parkinson
P2860
P3181
P356
10.1371/JOURNAL.PNTD.0001625
P407
P577
2012-01-01T00:00:00Z