APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival
about
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsTargeting DNA repair pathways for cancer treatment: what's new?Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell linesApurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer.Exploiting base excision repair to improve therapeutic approaches for pancreatic cancerSmall-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neuronsSTAT3 in the systemic inflammation of cancer cachexia.Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer TherapeuticsA review on protein-protein interaction network of APE1/Ref-1 and its associated biological functions.Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral NeuropathyRef-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel.APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells.Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survivalThe regulatory role of APE1 in epithelial-to-mesenchymal transition and in determining EGFR-TKI responsiveness in non-small-cell lung cancer
P2860
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P2860
APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@ast
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@en
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@nl
type
label
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@ast
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@en
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@nl
prefLabel
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@ast
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@en
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@nl
P2093
P2860
P1433
P1476
APE1/Ref-1 regulates STAT3 tra ...... ancreatic cancer cell survival
@en
P2093
Angelo A Cardoso
Anirban Maitra
April M Reed
Mark R Kelley
Meihua Luo
Safi Shahda
Yanlin Jiang
P2860
P304
P356
10.1371/JOURNAL.PONE.0047462
P407
P577
2012-01-01T00:00:00Z