The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
about
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1The Tumorigenic Roles of the Cellular REDOX Regulatory SystemsEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleA genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survivalDiverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collectionUbiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5.Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues.A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells.Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.Common polymorphisms of the hOGG1, APE1 and XRCC1 genes correlate with the susceptibility and clinicopathological features of primary angle-closure glaucomaChemical shift assignments for human apurinic/apyrimidinic endonuclease 1.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Single cell trapping and DNA damage analysis using microwell arrays.Targeting DNA repair pathways for cancer treatment: what's new?Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein bindingRole of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathySmall molecule inhibitors of DNA repair nuclease activities of APE1.Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsInhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo.Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model.Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancerDevelopment and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell linesFunctional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expressionSpecific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell linesApurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growthTherapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repairKnock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionApurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages.Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).Design and activity of AP endonuclease-1 inhibitors.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms
P2860
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P2860
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The DNA base excision repair p ...... tic and chemopreventive target
@ast
The DNA base excision repair p ...... tic and chemopreventive target
@en
The DNA base excision repair p ...... tic and chemopreventive target
@nl
type
label
The DNA base excision repair p ...... tic and chemopreventive target
@ast
The DNA base excision repair p ...... tic and chemopreventive target
@en
The DNA base excision repair p ...... tic and chemopreventive target
@nl
prefLabel
The DNA base excision repair p ...... tic and chemopreventive target
@ast
The DNA base excision repair p ...... tic and chemopreventive target
@en
The DNA base excision repair p ...... tic and chemopreventive target
@nl
P3181
P1476
The DNA base excision repair p ...... tic and chemopreventive target
@en
P2093
Mark R Kelley
P304
P3181
P356
10.1016/J.MAM.2007.04.005
P407
P577
2007-05-03T00:00:00Z