The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis
about
Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid HomeostasisEmerging regulatory paradigms in glutathione metabolism.Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse LensNox4 Plays a Role in TGF-β-Dependent Lens Epithelial to Mesenchymal TransitionEvidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis.Reduced glutathione level promotes epithelial-mesenchymal transition in lens epithelial cells via a Wnt/β-catenin-mediated pathway: relevance for cataract therapy.Pathology of Mouse Models of Accelerated Aging.Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches.Quantitative proteomics analysis by iTRAQ in human nuclear cataracts of different ages and normal lens nuclei.Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens.Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins.Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration.Aberrant Epigenetic Alterations of Glutathione-S-Transferase P1 in Age-Related Nuclear Cataract.
P2860
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P2860
The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis
description
2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@ast
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@en
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@nl
type
label
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@ast
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@en
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@nl
prefLabel
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@ast
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@en
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@nl
P2093
P2860
P3181
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P1476
The LEGSKO mouse: a mouse mode ...... of lens glutathione synthesis
@en
P2093
Benlian Wang
Michael L Robinson
Vincent M Monnier
Xiaoqin Liu
Xingjun Fan
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0050832
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P577
2012-01-01T00:00:00Z