1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin
about
Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug developmentStructures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysisStructures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate ComplexesInhibition of 1-Deoxy- d -Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic StudiesStructural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098Alteration of the Flexible Loop in 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by FosmidomycinFosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathwaysLipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacyThe nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by DxsKinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.Targeting metalloproteins by fragment-based lead discovery.Systematics-guided bioprospecting for bioactive microbial natural products.Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspFExploring anti-TB leads from natural products library originated from marine microbes and medicinal plants.Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii.Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.LytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically RedundantResistance of Francisella novicida to fosmidomycin associated with mutations in the glycerol-3-phosphate transporter.Defining mycobacteria: Shared and specific genome features for different lifestylesMolecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.Targeting the formation of the cell wall core of M. tuberculosis.Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE.Conformational dynamics of the flexible catalytic loop in Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine.ENANTIOMERIC SYNTHESIS OF 2-C-METHYL-D-ERYTHRITOL 2, 4-CYCLODIPHOSPHATE.D-fructose-6-phosphate aldolase in organic synthesis: cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds.Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro.A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD).A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
P2860
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P2860
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin
description
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Dezember 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/12/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/12/01)
@nl
наукова стаття, опублікована в грудні 2005
@uk
مقالة علمية (نشرت في ديسمبر 2005)
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name
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
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1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@en
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@nl
type
label
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@ast
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@en
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@nl
prefLabel
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@ast
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@en
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@nl
P2093
P2860
P1476
1-Deoxy-D-xylulose 5-phosphate ...... ial resistance to fosmidomycin
@en
P2093
Ann Marie Bailey
Charles A. Testa
Dean C. Crick
Hataichanok Scherman
Merrill L. Schaeffer
Rakesh K. Dhiman
P2860
P304
P356
10.1128/JB.187.24.8395-8402.2005
P407
P577
2005-12-01T00:00:00Z