A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
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High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolismStudies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosisComparative and functional genomics of Rhodococcus opacus PD630 for biofuels developmentMycobacterial outer membranes: in search of proteinsPathogen roid rage: cholesterol utilization by Mycobacterium tuberculosisMycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-oneA flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolismActivity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosisMycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroidsThe Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infectionCharacterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosisLiver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in miceRhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificityUse of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophagesArylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discoveryThe tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triadThe molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerizationMycobacterium tuberculosis CYP130: CRYSTAL STRUCTURE, BIOPHYSICAL CHARACTERIZATION, AND INTERACTIONS WITH ANTIFUNGAL AZOLE DRUGSStructure of HsaD, a steroid-degrading hydrolase, fromMycobacterium tuberculosisX-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14 -Demethylase (CYP51)Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosisCharacterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol MetabolismBiochemical and structural characterization of CYP124: A methyl-branched lipid -hydroxylase from Mycobacterium tuberculosisStructural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGENStructure and Catalytic Mechanism of 3-Ketosteroid- 4-(5 )-dehydrogenase from Rhodococcus jostii RHA1 GenomeStructure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibileCharacterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatisPiperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside MacrophagesCrystal Structure and Site-directed Mutagenesis of 3-Ketosteroid 1-Dehydrogenase from Rhodococcus erythropolis SQ1 Explain Its Catalytic MechanismSubstrate Specificities and Conformational Flexibility of 3-Ketosteroid 9α-HydroxylasesStructure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversityShrinking the FadE proteome of Mycobacterium tuberculosis: insights into cholesterol metabolism through identification of an α2β2 heterotetrameric acyl coenzyme A dehydrogenase familyCytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputumRv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenaseSurface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophagesMycobacterium tuberculosis is able to accumulate and utilize cholesterolCholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptationsMycobacterial persistence requires the utilization of host cholesterolFunctional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acidsFunctional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses
P2860
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P2860
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
description
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2007
@ast
im Februar 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/02/06)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/02/06)
@nl
наукова стаття, опублікована в лютому 2007
@uk
name
A gene cluster encoding choles ...... ulosis survival in macrophages
@ast
A gene cluster encoding choles ...... ulosis survival in macrophages
@en
A gene cluster encoding choles ...... ulosis survival in macrophages
@nl
type
label
A gene cluster encoding choles ...... ulosis survival in macrophages
@ast
A gene cluster encoding choles ...... ulosis survival in macrophages
@en
A gene cluster encoding choles ...... ulosis survival in macrophages
@nl
prefLabel
A gene cluster encoding choles ...... ulosis survival in macrophages
@ast
A gene cluster encoding choles ...... ulosis survival in macrophages
@en
A gene cluster encoding choles ...... ulosis survival in macrophages
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
A gene cluster encoding choles ...... ulosis survival in macrophages
@en
P2093
Hirofumi Hara
Julian E Davies
Katherine Yam
Maarten H Wilbrink
Matthew C Anderton
Robert Van der Geize
William W Mohn
P2860
P304
P3181
P356
10.1073/PNAS.0605728104
P407
P577
2007-01-30T00:00:00Z