Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis
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Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin.The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infectionAtomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450Mycobacterium tuberculosis CYP130: CRYSTAL STRUCTURE, BIOPHYSICAL CHARACTERIZATION, AND INTERACTIONS WITH ANTIFUNGAL AZOLE DRUGSCharacterization of Active Site Structure in CYP121: A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37RvIdentification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosisInteraction of Mycobacterium tuberculosis CYP130 with Heterocyclic ArylaminesBiochemical and structural characterization of CYP124: A methyl-branched lipid -hydroxylase from Mycobacterium tuberculosisGlutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGENSubstrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURESStructure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE(CYP152L1) from theJeotgalicoccussp. 8456 BacteriumApplication of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosisKinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprAStructural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.Identification of small-molecule scaffolds for p450 inhibitorsThe Mycobacterium tuberculosis cytochrome P450 system.Characterization of Cupriavidus metallidurans CYP116B1--a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.CYP153A6, a soluble P450 oxygenase catalyzing terminal-alkane hydroxylation.Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.Spectroscopic features of cytochrome P450 reaction intermediatesThe Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets.The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways.Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials.Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.Spectroscopic studies of the cytochrome P450 reaction mechanisms.Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential cytochrome p450 of Mycobacterium tuberculosis.A natural heme-signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω-hydroxylation.Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway.Synthesis and biological activities of new hydrazide derivatives.Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.Novel family members of CYP109 from Sorangium cellulosum So ce56 exhibit characteristic biochemical and biophysical properties.Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3.
P2860
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P2860
Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis
description
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im September 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/09/20)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/09/20)
@nl
наукова стаття, опублікована у вересні 2002
@uk
مقالة علمية (نشرت في 20-9-2002)
@ar
name
Expression, purification and s ...... rom Mycobacterium tuberculosis
@ast
Expression, purification and s ...... rom Mycobacterium tuberculosis
@en
Expression, purification and s ...... rom Mycobacterium tuberculosis
@nl
type
label
Expression, purification and s ...... rom Mycobacterium tuberculosis
@ast
Expression, purification and s ...... rom Mycobacterium tuberculosis
@en
Expression, purification and s ...... rom Mycobacterium tuberculosis
@nl
prefLabel
Expression, purification and s ...... rom Mycobacterium tuberculosis
@ast
Expression, purification and s ...... rom Mycobacterium tuberculosis
@en
Expression, purification and s ...... rom Mycobacterium tuberculosis
@nl
P2093
P3181
P1476
Expression, purification and s ...... rom Mycobacterium tuberculosis
@en
P2093
Alison Richmond
Andrew W Munro
David Leys
Graeme A Reid
John Clarkson
Kirsty J McLean
Myles R Cheesman
Nicholas C Price
Stephen K Chapman
Stuart L Rivers
P304
P3181
P356
10.1016/S0162-0134(02)00479-8
P577
2002-09-01T00:00:00Z