A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity
about
Targeting DNA Replication Stress for Cancer TherapyThe utility of transposon mutagenesis for cancer studies in the era of genome editing.Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerProfile of veliparib and its potential in the treatment of solid tumorsGenome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.Hunting Viral Receptors Using Haploid CellsCombinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's SarcomaFunctional toxicology: tools to advance the future of toxicity testing.Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer.Haploid genomes illustrate epigenetic constraints and gene dosage effects in mammals.A nucleolus-predominant piggyBac transposase, NP-mPB, mediates elevated transposition efficiency in mammalian cells.Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.CRISPR/Cas9-mediated reporter knock-in in mouse haploid embryonic stem cells.Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9.Generation and application of mammalian haploid embryonic stem cells.Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells.[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancerOlaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparibMechanisms of resistance to therapies targeting BRCA-mutant cancers.High-Throughput Silencing Using the CRISPR-Cas9 System: A Review of the Benefits and Challenges.Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.Genome-wide mapping of cellular traits using yeast.A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy.A versatile genetic tool: haploid cells.ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells.Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens.BRCA Gene Mutations and Poly(ADP-Ribose) Polymerase Inhibitors in Triple-Negative Breast Cancer.PARP inhibition causes premature loss of cohesion in cancer cells.HaSAPPy: A tool for candidate identification in pooled forward genetic screens of haploid mammalian cells.Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.Establishment and Use of Mouse Haploid ES Cells.Transposons As Tools for Functional Genomics in Vertebrate Models.The rise of genomic profiling in ovarian cancer.TrapSeq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells.New tools for old drugs: Functional genetic screens to optimize current chemotherapy.
P2860
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P2860
A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity
description
2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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A genetic screen using the Pig ...... mediator of olaparib toxicity
@ast
A genetic screen using the Pig ...... mediator of olaparib toxicity
@en
A genetic screen using the Pig ...... mediator of olaparib toxicity
@nl
type
label
A genetic screen using the Pig ...... mediator of olaparib toxicity
@ast
A genetic screen using the Pig ...... mediator of olaparib toxicity
@en
A genetic screen using the Pig ...... mediator of olaparib toxicity
@nl
prefLabel
A genetic screen using the Pig ...... mediator of olaparib toxicity
@ast
A genetic screen using the Pig ...... mediator of olaparib toxicity
@en
A genetic screen using the Pig ...... mediator of olaparib toxicity
@nl
P2093
P2860
P50
P3181
P1433
P1476
A genetic screen using the Pig ...... mediator of olaparib toxicity
@en
P2093
Farah L Rehman
Fredrik Wallberg
Ilirjana Bajrami
Ioannis Assiotis
Iwanka Kozarewa
Kerry Fenwick
Rachel Brough
Stephen J Pettitt
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0061520
P407
P577
2013-01-01T00:00:00Z