The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis
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X-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium TuberculosisPathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosisDeletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent miceThe condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylationPhosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosisTargeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitorsA novel interaction linking the FAS-II and phthiocerol dimycocerosate (PDIM) biosynthetic pathways.Trafficking pathways of mycolic acids: structures, origin, mechanism of formation, and storage form of mycobacteric acids.Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes.Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone.Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition.Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.Targeting the formation of the cell wall core of M. tuberculosis.Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemiaThe Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.Fatty acid biosynthesis in actinomycetes.Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strainCharacterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene.Substrate recognition by β-ketoacyl-ACP synthases.Protein dynamics in iron-starved Mycobacterium tuberculosis revealed by turnover and abundance measurement using hybrid-linear ion trap-Fourier transform mass spectrometry.Characterization of MymA protein as a flavin-containing monooxygenase and as a target of isoniazid.
P2860
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P2860
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis
description
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
scientific journal article
@en
vedecký článok (publikovaný 2002/01/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/01/01)
@nl
наукова стаття, опублікована в січні 2002
@uk
مقالة علمية (نشرت عام 2002)
@ar
name
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@ast
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@en
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@nl
type
label
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@ast
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@en
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@nl
prefLabel
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@ast
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@en
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@nl
P356
P1433
P1476
The role of KasA and KasB in t ...... in Mycobacterium tuberculosis
@en
P2093
C. E. Barry
P304
P356
10.1054/TUBE.2002.0333
P577
2002-01-01T00:00:00Z