Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia - Wikidata - wikimedia - TriplyDB

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia

http://www.wikidata.org/entity/Q37383936

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A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA Structural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) Inhibitors Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching Use of temperature for standardizing the progression of Francisella tularensis in mice.Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response.The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.Bis-indolic compounds as potential new therapeutic alternatives for tularaemia.Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.

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Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia

http://www.wikidata.org/entity/Q37383936

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scientific article published on 04 September 2009

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Substituted diphenyl ethers as ...... or the treatment of tularaemia

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Journal of Antimicrobial Chemotherapy

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Substituted diphenyl ethers as ...... or the treatment of tularaemia

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Christopher am Ende

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Dennis L Knudson

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Hao Lu

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Kathleen England

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Nicole L Marlenee

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Susan E Knudson

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Todd J Sullivan

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P2860

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance

Biological and chemical terrorism: strategic plan for preparedness and response - recommendations of the CDC strategic planning workgroup

Molecular basis of triclosan activity

Structural basis and mechanism of enoyl reductase inhibition by triclosan

Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan

Molecular basis for triclosan activity involves a flipping loop in the active site

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK

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1052-1061

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scholarly article

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10.1093/JAC/DKP307

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5

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Richard Slayden

Richard A Bowen

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2009-09-04T00:00:00Z

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26793222

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19734171

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