Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia
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A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhAStructural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) InhibitorsNasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei InfectionsDiscovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matchingUse of temperature for standardizing the progression of Francisella tularensis in mice.Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensisMechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomalleiRadiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureusSubstituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response.The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.Bis-indolic compounds as potential new therapeutic alternatives for tularaemia.Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.
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P2860
Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Substituted diphenyl ethers as ...... or the treatment of tularaemia
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Substituted diphenyl ethers as ...... r the treatment of tularaemia.
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type
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Substituted diphenyl ethers as ...... or the treatment of tularaemia
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Substituted diphenyl ethers as ...... r the treatment of tularaemia.
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prefLabel
Substituted diphenyl ethers as ...... or the treatment of tularaemia
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Substituted diphenyl ethers as ...... r the treatment of tularaemia.
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P2093
P2860
P50
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Substituted diphenyl ethers as ...... or the treatment of tularaemia
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Christopher am Ende
Dennis L Knudson
Kathleen England
Nicole L Marlenee
Susan E Knudson
Todd J Sullivan
P2860
P304
P356
10.1093/JAC/DKP307
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P577
2009-09-04T00:00:00Z