Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates
about
Biotin synthesis begins by hijacking the fatty acid synthetic pathwayBiochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donorExploiting the Biosynthetic Potential of Type III Polyketide SynthasesLessons learned from the transformation of natural product discovery to a genome-driven endeavorDistinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassaA structure-based mechanism for benzalacetone synthase from Rheum palmatumStructural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativaCrystal Structure of Mycobacterium tuberculosis Polyketide Synthase 11 (PKS11) Reveals Intermediates in the Synthesis of Methyl-branched AlkylpyronesStructure/Function Analysis of a Type III Polyketide Synthase in the Brown Alga Ectocarpus siliculosus Reveals a Biochemical Pathway in Phlorotannin Monomer BiosynthesisStructural Basis for Cyclization Specificity of Two Azotobacter Type III Polyketide Synthases: A SINGLE AMINO ACID SUBSTITUTION REVERSES THEIR CYCLIZATION SPECIFICITYChemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plantsStructure-function relationships in plant phenylpropanoid biosynthesisA polyketide synthase of Plumbago indica that catalyzes the formation of hexaketide pyrones.Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells.Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.Investigation of cytochromes P450 in myxobacteria: excavation of cytochromes P450 from the genome of Sorangium cellulosum So ce56.Cyclization of aromatic polyketides from bacteria and fungiRole of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer.One-pot enzymatic synthesis of merochlorin A and B.Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation.Genomic basis for natural product biosynthetic diversity in the actinomycetesSynthesis of the α,ω-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway.New insights into the formation of fungal aromatic polyketides.Crystallization and preliminary crystallographic analysis of a novel plant type III polyketide synthase that produces pentaketide chromoneCrystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata.Novel properties of P450s in Streptomyces coelicolor.Evolving biosynthetic tangos negotiate mechanistic landscapes.Heterologous expression systems for polyketide synthases.Convergent strategies in biosynthesis.Towards a new science of secondary metabolism.Catalytic enantioselective decarboxylative reactions using organocatalysts.The biocatalytic repertoire of natural biaryl formation.Type III Polyketide Synthases: Functional Classification and Phylogenomics.Type III polyketide synthase repertoire in Zingiberaceae: computational insights into the sequence, structure and evolution.A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes.Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining.Evolutionary Implications and Physicochemical Analyses of Selected Proteins of Type III Polyketide Synthase Family.Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB.Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidasesA gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.
P2860
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P2860
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates
description
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im Oktober 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/10/22)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/10/22)
@nl
наукова стаття, опублікована в жовтні 2004
@uk
name
Crystal structure of a bacteri ...... ctive polyketide intermediates
@ast
Crystal structure of a bacteri ...... ctive polyketide intermediates
@en
Crystal structure of a bacteri ...... ctive polyketide intermediates
@nl
type
label
Crystal structure of a bacteri ...... ctive polyketide intermediates
@ast
Crystal structure of a bacteri ...... ctive polyketide intermediates
@en
Crystal structure of a bacteri ...... ctive polyketide intermediates
@nl
prefLabel
Crystal structure of a bacteri ...... ctive polyketide intermediates
@ast
Crystal structure of a bacteri ...... ctive polyketide intermediates
@en
Crystal structure of a bacteri ...... ctive polyketide intermediates
@nl
P2093
P2860
P356
P1476
Crystal structure of a bacteri ...... ctive polyketide intermediates
@en
P2093
Daniel W Udwary
Jean-Luc Ferrer
Joseph P Noel
Marianne E Bowman
Michael B Austin
Miho Izumikawa
P2860
P304
45162-45174
P356
10.1074/JBC.M406567200
P407
P577
2004-07-20T00:00:00Z