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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolutionFunction-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropicaGenome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropicaLessons from the past and charting the future of marine natural products drug discovery and chemical biologyStructural Determinants and Modulation of Substrate Specificity in Phenylalanine-Tyrosine Ammonia-LyasesDiscovery of Two Cyanobacterial Phenylalanine Ammonia Lyases: Kinetic and Structural Characterization † , ‡Mechanistic Insights into Water Activation in SAM Hydroxide Adenosyltransferase (duf-62)Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangementEnzyme Inhibition by Hydroamination: Design and Mechanism of a Hybrid Carmaphycin-Syringolin Enone Proteasome InhibitorSharing and community curation of mass spectrometry data with Global Natural Products Social Molecular NetworkingCrystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediatesExpression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2)Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilisBiosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pairMass spectral molecular networking of living microbial colonies.Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporusMolecular evidence for a uniform microbial community in sponges from different oceans.Probing the compatibility of type II ketosynthase-carrier protein partners.Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses.Biosynthesis of polybrominated aromatic organic compounds by marine bacteria.NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide DiscoveryFungal polyketide engineering comes of age.A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling.Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.Automated genome mining of ribosomal peptide natural products.The marine actinomycete genus Salinispora: a model organism for secondary metabolite discoveryBiochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins.One-pot enzymatic synthesis of merochlorin A and B.Unusual flavoenzyme catalysis in marine bacteria.Discovery of a new bacterial polyketide biosynthetic pathway.Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.Biosynthesis and attachment of novel bacterial polyketide synthase starter units.Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus"Genomic basis for natural product biosynthetic diversity in the actinomycetes
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P50
description
hulumtues
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onderzoeker
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հետազոտող
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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Bradley S Moore
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P106
P21
P31
P496
0000-0002-4652-1253