NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
about
hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNANUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrestStructural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine MonophosphateNew insights into decapping enzymes and selective mRNA decayThe human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic coreMultiple Nudix family proteins possess mRNA decapping activityDefects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNAA disease spectrum for ITPA variation: advances in biochemical and clinical researchPivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells.DNA repair mechanisms in dividing and non-dividing cells.Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defectsDeoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cellsITPA (inosine triphosphate pyrophosphatase): from surveillance of nucleotide pools to human disease and pharmacogeneticsModulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.The druggability of intracellular nucleotide-degrading enzymes.Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.Nudix hydrolases degrade protein-conjugated ADP-ribose.Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma.Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera.A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.ITPA hydrolyses ITP to IMPITPA hydrolyses XTP to XMPITPA hydrolyses dITP to dIMP
P2860
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P2860
NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
description
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im Mai 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/05/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/05/01)
@nl
наукова стаття, опублікована в травні 2010
@uk
مقالة علمية (نشرت في مايو 2010)
@ar
name
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@ast
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@en
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@nl
type
label
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@ast
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@en
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@nl
prefLabel
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@ast
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@en
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@nl
P2093
P2860
P3181
P356
P1476
NUDT16 and ITPA play a dual pr ...... om nucleotide pools in mammals
@en
P2093
Daisuke Tsuchimoto
Kunihiko Sakumi
Mizuki Ohno
Nona Abolhassani
Teruaki Iyama
P2860
P304
P3181
P356
10.1093/NAR/GKP1250
P407
P577
2010-01-15T00:00:00Z