Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
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GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localizationSki is involved in transcriptional regulation by the repressor and full-length forms of Gli3mBtd is required to maintain signaling during murine limb developmentMutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signalingEssential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagusDistinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud developmentCharacterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesisGata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb DevelopmentMutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathiesLimb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth developmentIdentification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functionsMsx1 and Msx2 in limb mesenchyme modulate digit number and identityThe zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signalingDigit patterning during limb development as a result of the BMP-receptor interactionHeterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin developmentDevelopmental pathways: Sonic hedgehog-Patched-GLIRegulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma.Gli genes in development and cancer.Perspectives on the evolutionary origin of tetrapod limbs.Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.Nipbl and mediator cooperatively regulate gene expression to control limb development.THE EFFECTS OF 5-AZA-2'-DEOXYCYTIDINE (D-AZA) ON SONIC HEDGEHOG EXPRESSION IN MOUSE EMBRYONIC LIMB BUDS.The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.Patterning the limb before and after SHH signalling.Sonic hedgehog: restricted expression and limb dysmorphologies.Developmental mechanisms underlying polydactyly in the mouse mutant Doublefoot.T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressorGLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog PathwayA shift in anterior-posterior positional information underlies the fin-to-limb evolution.Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development.Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.Whole-genome resequencing of Xishuangbanna fighting chicken to identify signatures of selectionThe spectrum of hand and foot malformations in patients with Greig cephalopolysyndactyly.Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death.SHH Protein Variance in the Limb Bud Is Constrained by Feedback Regulation and Correlates with Altered Digit Patterning.Boning up on glypicans--opportunities for new insights into bone biology.Insights on the role of hox genes in the emergence of the pentadactyl ground state.
P2860
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P2860
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
description
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im März 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/03/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/03/01)
@nl
наукова стаття, опублікована в березні 1997
@uk
مقالة علمية (نشرت في مارس 1997)
@ar
name
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@ast
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@en
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@nl
type
label
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@ast
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@en
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@nl
prefLabel
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@ast
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@en
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@nl
P2093
P3181
P1476
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
@en
P2093
P304
P3181
P356
10.1016/S0925-4773(97)00656-4
P577
1997-03-01T00:00:00Z