Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene
about
Bile acid transporters in health and diseaseBile Acid Metabolism and Signaling in Cholestasis, Inflammation, and CancerStructural and functional insights into enzymes of the vitamin K cycleBile acid signaling in metabolic disease and drug therapyProtective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicityHepatitis B spliced protein (HBSP) promotes the carcinogenic effects of benzo [alpha] pyrene by interacting with microsomal epoxide hydrolase and enhancing its hydrolysis activityEffect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposureIntronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoterDevelopment of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studiesAnti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal UlcersEffects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in miceRadiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBAIncreased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase PiHepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasisMicrosomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human diseaseDisturbance in testosterone production in leydig cells by polycyclic aromatic hydevrepocarbonsSensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient miceLangerhans cells facilitate epithelial DNA damage and squamous cell carcinomaInhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity.7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide.Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated miceAcute 7,12-dimethylbenz[a]anthracene exposure causes differential concentration-dependent follicle depletion and gene expression in neonatal rat ovaries.Functional analysis of human microsomal epoxide hydrolase genetic variants.Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1).Cytochrome P450 2E1: its clinical and toxicological role.Bile acid regulation of hepatic physiology: I. Hepatocyte transport of bile acids.The role of epoxide hydrolases in health and disease.The vitamin K cycle.Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damageBenzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphismsPurified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2Impact of obesity on ovotoxicity induced by 7,12-dimethylbenz[a]anthracene in miceRole of gene knockout and transgenic mice in the study of xenobiotic metabolism.Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicityCytochrome P450s and other enzymes in drug metabolism and toxicity.Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice.Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5'-untranslated regionSoluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia.The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE.
P2860
Q24647024-AD3A7142-549B-4DC9-9BD5-C7543FA92F71Q26800206-FE5B79D2-3A4D-4142-926B-B3753E053D56Q28086880-B2EEE768-695F-4390-92CF-1C714D39D023Q28244875-3FADE711-9F90-4388-AD55-38D0CF9AD575Q28383035-C1133205-8610-45FF-A9A1-AB49036078D7Q28384850-1DAED218-EFFA-40E4-AD01-89069A80E138Q28385489-78B0B7B4-ED86-4B42-B91B-26BCC83B5B72Q28386991-F468FA74-F0ED-4C76-9B1B-E9BF68314D6EQ28388362-35B5426E-BFA5-40CF-8189-DA5FE12BEDB4Q28395478-463744E2-3CE4-4229-B12C-EE6763B311E4Q28397525-AD1CAFDF-AC2F-4F2E-BD87-3B561DC6E453Q28478400-6E2F0004-3FD7-4D32-9116-3305188E90BEQ28589006-32C16163-29E9-414C-B64A-A7CD8B53F552Q28591211-04254F14-4BEE-498A-AEE5-883F37DEC46AQ28608628-1FC3777F-F0A9-4532-AACB-8736652DCA13Q28648187-7417401F-9D8B-4343-9E51-4063ADF693F3Q29615438-EB78285F-F01C-4995-BA1C-95CA926C80E8Q30543679-BD9C315A-E796-4738-AE64-0DFCFD139C76Q33596274-03415B49-E3BB-4624-843C-70EF09C32AF3Q33676655-4F5391DF-A93D-4DC3-B122-735AF1CD28C5Q33787781-0D38F84F-37EE-49FE-8A26-01695A232182Q33828909-16A67F00-6A6F-48AA-B1EA-AECAFA862321Q33881654-EE03F048-9AD8-4544-A760-B0DC6C7EC092Q33881757-82E72EBC-3B0B-42DE-BA8F-773D399BFD32Q33962207-04E40FEF-B183-4482-A17E-54D3A116B347Q34170675-25382605-7229-4BB1-B775-19A0B5A3013DQ34440084-403957A6-F10E-4DBF-AC53-63EA35C00E6EQ34443182-27D4D0CA-FC12-42E4-AACF-F84ED77C59ADQ34764184-FDC33DC6-BDCE-47E1-A4FC-F138A102BB96Q35047219-BD2349C1-8B48-4A5F-B1CD-838D41EE725BQ35133483-BAF3F77B-73C8-4892-A1E0-002252F8541BQ35221146-B6551D75-C825-4A48-8EE8-C2001C378B2CQ35618049-7D6730B8-47D9-4989-A062-7D748213F9A7Q35620649-28E8A987-E229-4534-9944-027114EFC986Q35985194-8FA46955-23E2-4180-B2B5-F7FDF6E83AA7Q36439150-64E71E56-F932-4549-B61E-EBDC36688820Q36640557-6E2CD5C3-14F2-44ED-AB4B-99F60C92241FQ36932875-97087B3E-DFC9-469A-9267-A46ED50E656CQ36996066-44571CCE-C6D7-4CCA-BC51-30B23C9614E4Q37078658-94069699-652F-4005-A150-475EE50F331F
P2860
Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene
description
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im August 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/08/20)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/08/20)
@nl
наукова стаття, опублікована в серпні 1999
@uk
name
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@ast
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@en
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@nl
type
label
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@ast
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@en
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@nl
prefLabel
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@ast
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@en
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@nl
P2093
P2860
P3181
P356
P1476
Targeted disruption of the mic ...... 7,12-dimethylbenz[a]anthracene
@en
P2093
F. J. Gonzalez
H. V. Gelboin
P. Fernandez-Salguero
T. J. Yang
P2860
P304
23963–23968
P3181
P356
10.1074/JBC.274.34.23963
P407
P577
1999-08-20T00:00:00Z