Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.
about
Mitochondrial DNA damage and its consequences for mitochondrial gene expressionProcessing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesteraseTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitorsTranscription-dependent degradation of topoisomerase I-DNA covalent complexesRepair of topoisomerase I-mediated DNA damage.The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adeninePosition- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures.Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site.Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.Overexpression of type I topoisomerases sensitizes yeast cells to DNA damage.Interaction of human nuclear topoisomerase I with guanosine quartet-forming and guanosine-rich single-stranded DNA and RNA oligonucleotides.Benzo[a]pyrene-dG adduct interference illuminates the interface of vaccinia topoisomerase with the DNA minor groove.Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.DNA cleavage assay for the identification of topoisomerase I inhibitors.p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
P2860
Q27001150-23D3E68F-A61D-4657-BE60-79E4AEE38F40Q33584109-7A48DB03-7849-4267-B001-8539E3389842Q33875792-30F0F260-FA3E-4CFA-8F70-DCB65472FDFFQ33963811-4AD6A1E0-73C2-4A11-A217-89BE1723D381Q34017010-7A4A6E19-0DDA-4CBF-B233-4D878178FC73Q34021070-8475A493-6BA0-46DB-A552-722FE483F79CQ34784817-0413C317-EEA8-457C-A62A-422A5E4581DEQ36557533-4C59B75D-03C3-4884-9E22-E0E0D03B2065Q36777804-8547F963-64B8-490C-BB5D-9266CAD064E7Q37258373-AC2BC1DF-012D-42FA-B99E-2B48C29571CEQ37564077-B0CF3722-D8F8-43C5-B826-BCFE689392D4Q37592361-69E3D985-5DC5-490B-A2EB-0652B9D2E5DAQ38261264-4458B380-F0F4-4321-882E-C1C94B996F5CQ38292238-4A783BD8-4DCF-4D32-B7BA-1E1E0559D873Q38310166-1BA6CD23-BEDA-475C-97A9-0CDD5C719FFFQ38347856-1A5F8CE1-4DD7-4CB1-A965-7135D55E53A1Q43608431-09608195-3512-4E8F-9FF3-AC2440B7DAD6Q43833664-1EF93B9A-8CAC-4244-9CEE-3FE61F379538Q44276073-E480C2C7-6486-47A5-A195-67E5538180FFQ44378806-CB3C9ED3-10C9-4D40-861B-7EE02ED27498Q46312378-9ABE63D1-F3E7-4998-9D86-6EA00F73070EQ46890874-ED19183B-3184-4DC9-B57C-59E17DFD4FA5
P2860
Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Benzo[a]pyrene diol epoxide ad ...... her topoisomerase I cleavages.
@en
type
label
Benzo[a]pyrene diol epoxide ad ...... her topoisomerase I cleavages.
@en
prefLabel
Benzo[a]pyrene diol epoxide ad ...... her topoisomerase I cleavages.
@en
P2093
P2860
P356
P1476
Benzo[a]pyrene diol epoxide ad ...... her topoisomerase I cleavages.
@en
P2093
P2860
P304
P356
10.1073/PNAS.040397497
P407
P577
2000-02-01T00:00:00Z