DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
about
The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiencyIn vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complexPhosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinaseThe centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosisOncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switchingMouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaksExtrachromosomal microDNAs and chromosomal microdeletions in normal tissuesFunctional redundancy between DNA ligases I and III in DNA replication in vertebrate cellsEukaryotic DNA ligases: structural and functional insightsDNA damage response and Ku80 function in the vertebrate embryo.Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.Genome wide distribution of illegitimate recombination events in Kluyveromyces lactisDNA repair and aging: the impact of the p53 familyInvolvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryosp53 in the DNA-Damage-Repair ProcessSnaps and mends: DNA breaks and chromosomal translocationsHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsHuman LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunctionNuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cellsThe response to and repair of RAG-mediated DNA double-strand breaksNon-homologous end-joining, a sticky affairRole of non-homologous end joining in V(D)J recombinationRad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stabilityAn essential function for NBS1 in the prevention of ataxia and cerebellar defectsInvolvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damageDefective neurogenesis resulting from DNA ligase IV deficiency requires AtmDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseRad50 is dispensable for the maintenance and viability of postmitotic tissuesGenetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and developmentDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsp53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient miceSelective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system developmentEmbryonic expression and regulation of the large zinc finger protein KRCThe role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotectionPARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathwaysDevelopmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient miceContribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaksmultiDE: a dimension reduced model based statistical method for differential expression analysis using RNA-sequencing data with multiple treatment conditions.
P2860
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P2860
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
description
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/06/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/06/01)
@nl
наукова стаття, опублікована в червні 2000
@uk
مقالة علمية (نشرت في يونيو 2000)
@ar
name
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@ast
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@en
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@nl
type
label
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@ast
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@en
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@nl
prefLabel
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@ast
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@en
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@nl
P2093
P3181
P1433
P1476
DNA ligase IV deficiency in mi ...... lethality via the p53 pathway
@en
P2093
D. O. Ferguson
J. M. Sekiguchi
J. P. Manis
K. M. Frank
N. E. Sharpless
R. A. DePinho
P304
P3181
P356
10.1016/S1097-2765(00)80264-6
P577
2000-06-01T00:00:00Z