SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells
about
Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells.Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.Three interacting genomic loci incorporating two novel mutations underlie the evolution of diet-induced diabetes.Changes in C57BL6 Mouse Hippocampal Transcriptome Induced by Hypergravity Mimic Acute Corticosterone-Induced StressGenome-wide analysis of tunicamycin-induced endoplasmic reticulum stress response and the protective effect of endoplasmic reticulum inhibitors in neonatal rat cardiomyocytes.Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.
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SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells
description
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Mai 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/05/01)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/05/01)
@nl
наукова стаття, опублікована в травні 2013
@uk
مقالة علمية (نشرت في مايو 2013)
@ar
name
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@ast
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@en
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@nl
type
label
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@ast
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@en
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@nl
prefLabel
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@ast
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@en
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@nl
P2093
P921
P356
P1476
SDF2L1 interacts with the ER-a ...... oinsulin in pancreatic β-cells
@en
P2093
Akansha Tiwari
Allen Volchuk
Emma M. Allister
Irmgard Schuiki
Liling Zhang
Michael B. Wheeler
P304
P356
10.1242/JCS.117374
P407
P577
2013-05-01T00:00:00Z