Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice - Wikidata - wikimedia - TriplyDB

Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice

Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice

http://www.wikidata.org/entity/Q28508144

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The role of poly(ADP-ribose) in the DNA damage signaling network Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?Poly (ADP-ribose) in the pathogenesis of Parkinson's disease Paternal poly (ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase.Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles.Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase.Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation.Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence.Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells.Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice.Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase PARPs and ADP-Ribosylation: 50 Years … and Counting.ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).Poly(ADP-ribosylation) and genomic stability.CHFR is important for the first wave of ubiquitination at DNA damage sites PolyADP-ribosylation and cancer.PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways.PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency Poly-ADP-ribose polymerase: machinery for nuclear processes.Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose).Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.The Sound of Silence: RNAi in Poly (ADP-Ribose) Research The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.Macro domains as metabolite sensors on chromatin.

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Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice

http://www.wikidata.org/entity/Q28508144

description

2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2004

@ast

im August 2004 veröffentlichter wissenschaftlicher Artikel

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scientific journal article

@en

vedecký článok (publikovaný 2004/08/01)

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vědecký článek publikovaný v roce 2004

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wetenschappelijk artikel (gepubliceerd op 2004/08/01)

@nl

наукова стаття, опублікована в серпні 2004

@uk

مقالة علمية (نشرت في أغسطس 2004)

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name

Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

@ast

Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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type

label

Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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MCB.24.16.7163-7178.2004

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Molecular and Cellular Biology

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Depletion of the 110-kilodalto ...... c and endotoxic stress in mice

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Donna L. Coyle

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Elaine L. Jacobson

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Mirella L. Meyer-Ficca

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Myron K. Jacobson

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Ralph G. Meyer

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Ulrich Cortes

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Virginie Petrilli

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Wei-Min Tong

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Zdenko Herceg

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Zhao-Qi Wang

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P2860

Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells

Tim23 links the inner and outer mitochondrial membranes.

Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein

Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

Poly(ADPribosyl)ation system in rat germinal cells at different stages of differentiation

Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells

Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

The immunopathogenesis of sepsis

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