Neurological abnormalities in a knock-in mouse model of Huntington's disease
about
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicityInteraction of Huntington disease protein with transcriptional activator Sp1Spontaneous generation of prion infectivity in fatal familial insomnia knockin miceTowards a transgenic model of Huntington's disease in a non-human primateIntracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseasesTransgenic nonhuman primates for neurodegenerative diseasesGait dynamics in mouse models of Parkinson's disease and Huntington's disease.Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-ReviewDeveloping stem cell therapies for juvenile and adult-onset Huntington's diseaseHuntington's disease: the past, present, and future search for disease modifiers.Transgenic animal models for study of the pathogenesis of Huntington's disease and therapyMouse models of polyglutamine diseases: review and data table. Part IHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Genetics and neuropathology of Huntington's diseaseSuppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s DiseaseHDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophyHDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegenerationHuman-to-mouse prion-like propagation of mutant huntingtin protein.Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/2 mouse model of HDCorrelations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/1 mouse model of Huntington's diseaseA universal mechanism ties genotype to phenotype in trinucleotide diseasesThe chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's diseaseHuntingtin: alive and well and working in middle managementSIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisHuntingtin and its role in neuronal degenerationMitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes.A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleusDysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's diseaseThe operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's diseaseCellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic miceScalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinNFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapyA gene-targeted mouse model for chorea-acanthocytosisGenetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's diseaseOnset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease.Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice
P2860
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P2860
Neurological abnormalities in a knock-in mouse model of Huntington's disease
description
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Januar 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/01/15)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/01/15)
@nl
наукова стаття, опублікована в січні 2001
@uk
مقالة علمية (نشرت في 15-1-2001)
@ar
name
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@ast
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@en
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@nl
type
label
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@ast
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@en
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@nl
prefLabel
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@ast
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@en
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@nl
P2093
P3181
P356
P1476
Neurological abnormalities in a knock-in mouse model of Huntington's disease
@en
P2093
A B Crouse
J A Cearley
P J Detloff
S Tallaksen-Greene
P304
P3181
P356
10.1093/HMG/10.2.137
P577
2001-01-01T00:00:00Z