Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity - Wikidata - wikimedia - TriplyDB

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

http://www.wikidata.org/entity/Q24317318

about

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle GARS axonopathy: not every neuron's cup of tRNA Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases Sumoylation in Synaptic Function and Dysfunction Treatment of Huntington's disease.Iron dysregulation in Huntington's disease Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease Huntington's disease: underlying molecular mechanisms and emerging concepts Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.Mechanisms, regulation and consequences of protein SUMOylation The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.Exploration of panviral proteome: high-throughput cloning and functional implications in virus-host interactions Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation Pharmacokinetics of memantine in rats and mice A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.Detection, validation, and downstream analysis of allelic variation in gene expression Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion.Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice.Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1).Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease Sumo-dependent substrate targeting of the SUMO protease Ulp1 Rhes suppression enhances disease phenotypes in Huntington's disease mice Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease.Hydrogen sulfide as a gasotransmitter.Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.

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P2860

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

http://www.wikidata.org/entity/Q24317318

description

2009 nî lūn-bûn

@nan

2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@ast

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@en

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@en-gb

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@nl

type

label

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@ast

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@en

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@en-gb

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@nl

prefLabel

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@ast

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@en

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@en-gb

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@nl

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SCIENCE.1172871

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Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

@en

P2093

Katherine M Sixt

http://www.w3.org/2001/XMLSchema#string

Roxanne Barrow

http://www.w3.org/2001/XMLSchema#string

Srinivasa Subramaniam

http://www.w3.org/2001/XMLSchema#string

P2860

SUMO modification of Huntingtin and Huntington's disease pathology

The nucleoporin RanBP2 has SUMO1 E3 ligase activity

The polycomb protein Pc2 is a SUMO E3

Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON

The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors

Concepts in sumoylation: a decade on

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

Neurological abnormalities in a knock-in mouse model of Huntington's disease

Rhes: A striatal-specific Ras homolog related to Dexras1

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1327-30

http://www.w3.org/2001/XMLSchema#string

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scholarly article

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2001483

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10.1126/SCIENCE.1172871

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5932

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324

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Solomon Halbert Snyder

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2009-06-05T00:00:00Z

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26268387

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19498170

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corpus striatum

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2745286

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