Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat
about
Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node diseaseTargeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-BEffects of Na(+)/Ca(2+) exchanger downregulation on contractility and [Ca(2+)](i) transients in adult rat myocytesMolecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscleImpaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafishCalcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts.Mathematical model of mouse embryonic cardiomyocyte excitation-contraction coupling.Atrioventricular conduction and arrhythmias at the initiation of beating in embryonic mouse hearts.Vascular remodeling of the mouse yolk sac requires hemodynamic force.Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells.Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions.A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high.Multiple Calcium Export Exchangers and Pumps Are a Prominent Feature of Enamel Organ Cells.The effects of hemodynamic force on embryonic development.The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.Invited review: mechanisms of calcium handling in smooth muscles.The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium.Endurance exercise training reduces cardiac sodium/calcium exchanger expression in animals susceptible to ventricular fibrillation.Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes.Current perspectives of electrical remodeling and its therapeutic implications.A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.Development of structures and transport functions in the mouse placenta.Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethalityCross talk between cell-cell and cell-matrix adhesion signaling pathways during heart organogenesis: implications for cardiac birth defects.Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculatureExtracellular matrix and the mechanics of large artery development.Vascular Na+/Ca2+ exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension.Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.What determines blood vessel structure? Genetic prespecification vs. hemodynamics.Na+/Ca2+ exchange as a drug target--insights from molecular pharmacology and genetic engineering.Vitamin D and human health: lessons from vitamin D receptor null mice.Designing heart performance by gene transfer.Calcium handling precedes cardiac differentiation to initiate the first heartbeatTropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development.MicroRNA-214 antagonism protects against renal fibrosis.Engineering of arteries in vitro.Vascular development and hemodynamic force in the mouse yolk sac.Arrhythmias in the developing heart.
P2860
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P2860
Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat
description
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im November 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/11/24)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/11/24)
@nl
наукова стаття, опублікована в листопаді 2000
@uk
name
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@ast
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@en
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@nl
type
label
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@ast
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@en
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@nl
prefLabel
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@ast
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@en
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@nl
P2093
P3181
P356
P1476
Targeted disruption of Na+/Ca2 ...... tosis and defects in heartbeat
@en
P2093
A. Nishida
K. Kobayashi
K. Wakimoto
M. Shigekawa
P304
36991–36998
P3181
P356
10.1074/JBC.M004035200
P407
P577
2000-11-24T00:00:00Z