Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development.
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Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cellsTropomodulin capping of actin filaments in striated muscle development and physiologyKnockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethalityTropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiologyTmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lensLmod2 piggyBac mutant mice exhibit dilated cardiomyopathy.Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis.Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeletonPointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers.Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryoPhosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.Dynamic regulation of sarcomeric actin filaments in striated muscleIdentification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes.Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis.Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers.DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in DrosophilaLens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells.Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortexTropomodulins and tropomyosins: working as a teamTropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells.Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin ruler.Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens.Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genesEnucleate or replicate? Ask the cytoskeleton.Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.The functional diversity of essential genes required for mammalian cardiac development.The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics.Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles.Actin in striated muscle: recent insights into assembly and maintenanceOverview of the Muscle Cytoskeleton.Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle.Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics.Stabilization of F-actin by tropomyosin isoforms regulates the morphology and mechanical behavior of red blood cells.Characterizing interaction forces between actin and proteins of the tropomodulin family reveals the presence of the N-terminal actin-binding site in leiomodin.
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Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tropomodulin1 is required in t ...... r mouse embryonic development.
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Tropomodulin1 is required in t ...... r mouse embryonic development.
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type
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Tropomodulin1 is required in t ...... r mouse embryonic development.
@en
Tropomodulin1 is required in t ...... r mouse embryonic development.
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Tropomodulin1 is required in t ...... r mouse embryonic development.
@en
Tropomodulin1 is required in t ...... r mouse embryonic development.
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P2093
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Tropomodulin1 is required in t ...... r mouse embryonic development.
@en
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Caroline R McKeown
Jeannette Moyer
Mark A Sussman
Roberta B Nowak
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P304
P356
10.1161/CIRCRESAHA.108.178749
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P577
2008-10-16T00:00:00Z