WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells
about
Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stressThe E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulumWolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cellsWFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulumEndoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetesXenobiotic perturbation of ER stress and the unfolded protein responseCalcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosisCisd2 deficiency drives premature aging and causes mitochondria-mediated defects in miceCell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesAnnual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.Congenital central diabetes insipidus and optic atrophy in a Wolfram newborn: is there a role for WFS1 gene in neurodevelopment?Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application.Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function.Protective unfolded protein response in human pancreatic beta cells transplanted into mice.Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscleGroup VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.A novel CISD2 intragenic deletion, optic neuropathy and platelet aggregation defect in Wolfram syndrome type 2.Wolfram syndrome in the Japanese population; molecular analysis of WFS1 gene and characterization of clinical features.Early brain vulnerability in Wolfram syndrome.CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells.A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis.Central nervous system PET-CT imaging reveals regional impairments in pediatric patients with Wolfram syndromeA WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.Impairment of visual function and retinal ER stress activation in Wfs1-deficient mice.A review of the mammalian unfolded protein response.Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes.Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.Selective cognitive and psychiatric manifestations in Wolfram Syndrome.Glycemic variability in patients with Wolfram syndrome is lower than in type 1 diabetes.A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2Circadian control of β-cell function and stress responses.RNA-sequencing of WFS1-deficient pancreatic islets.Phenotypic characteristics of early Wolfram syndromeThe unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetesThe group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.Upregulation of p21 activates the intrinsic apoptotic pathway in β-cellsA link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β).
P2860
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P2860
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells
description
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Mai 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/05/15)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/05/15)
@nl
наукова стаття, опублікована в травні 2006
@uk
مقالة علمية (نشرت في 15-5-2006)
@ar
name
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@ast
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@en
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@nl
type
label
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@ast
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@en
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@nl
prefLabel
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@ast
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@en
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@nl
P2093
P2860
P921
P3181
P356
P1476
WFS1-deficiency increases endo ...... cally in pancreatic beta-cells
@en
P2093
Akira Tamura
Chihiro Satake
Daisuke Takei
Fumi Tashiro
Hideki Katagiri
Hiroyuki Aburatani
Hisamitsu Ishihara
Jun-ichi Miyazaki
Rui Takahashi
P2860
P304
P3181
P356
10.1093/HMG/DDL081
P577
2006-05-15T00:00:00Z