The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionEffects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexinCharacterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetesInhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levelsCalcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosisSpontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1Evidence for proteolytic processing and stimulated organelle redistribution of iPLA(2)beta.Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development.Regulation of phosphatidic Acid metabolism by sphingolipids in the central nervous systemCancer treatment strategies targeting sphingolipid metabolism.Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells.Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signalingCeramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosisRoles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoformGroup VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agentsChop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagyA link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β).Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cellsRole of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.Role of Ca2+-independent phospholipase A2 in cell growth and signaling.Intracellular- and extracellular-derived Ca(2+) influence phospholipase A(2)-mediated fatty acid release from brain phospholipids.Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cellsAltered ceramide acyl chain length and ceramide synthase gene expression in Parkinson’s disease.Unique sphingomyelin patches are targets of a beta-cell-specific antibody.Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation.Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)
P2860
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P2860
The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The group VIA calcium-independ ...... s by neutral sphingomyelinase.
@en
type
label
The group VIA calcium-independ ...... s by neutral sphingomyelinase.
@en
prefLabel
The group VIA calcium-independ ...... s by neutral sphingomyelinase.
@en
P2093
P2860
P356
P1433
P1476
The group VIA calcium-independ ...... ns by neutral sphingomyelinase
@en
P2093
Alan Bohrer
Haowei Song
Sasanka Ramanadham
Sheng Zhang
Xiaoyong Lei
P2860
P304
10170-10185
P356
10.1021/BI700017Z
P407
P577
2007-08-09T00:00:00Z