Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation
about
Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA TargetTinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across speciesLethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasisAblation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformationPoint mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes.Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development.NKX2-5 mutations in an inbred consanguineous population: genetic and phenotypic diversity.Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.Mutation of a common amino acid in NKX2.5 results in dilated cardiomyopathy in two large families.The emerging genetic landscape underlying cardiac conduction system function.Cardiomyocyte specific deletion of PP2A causes cardiac hypertrophy.Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.GATA4 transgenic mice as an in vivo model of congenital heart disease.Heart Failure Induced by Perinatal Ablation of Cardiac Myosin Light Chain Kinase.Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation.DeGNServer: deciphering genome-scale gene networks through high performance reverse engineering analysisBRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage.Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy
P2860
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P2860
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation
description
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im September 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2009/09/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/09/01)
@nl
наукова стаття, опублікована у вересні 2009
@uk
مقالة علمية (نشرت في سبتمبر 2009)
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name
Slow progressive conduction an ...... ocyte terminal differentiation
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Slow progressive conduction an ...... ocyte terminal differentiation
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Slow progressive conduction an ...... ocyte terminal differentiation
@nl
type
label
Slow progressive conduction an ...... ocyte terminal differentiation
@ast
Slow progressive conduction an ...... ocyte terminal differentiation
@en
Slow progressive conduction an ...... ocyte terminal differentiation
@nl
prefLabel
Slow progressive conduction an ...... ocyte terminal differentiation
@ast
Slow progressive conduction an ...... ocyte terminal differentiation
@en
Slow progressive conduction an ...... ocyte terminal differentiation
@nl
P2093
P2860
P3181
P1476
Slow progressive conduction an ...... ocyte terminal differentiation
@en
P2093
Ellen O Weinberg
Hideko Kasahara
Hiroko Wakimoto
Jonathan T Lu
Kenneth R Chien
Laura E Briggs
Melissa H Marks
Morihiko Takeda
Sonisha A Warren
P2860
P2888
P304
P3181
P356
10.1038/LABINVEST.2009.59
P577
2009-06-22T00:00:00Z
P5875
P6179
1030127705