Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
about
Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAPThe novel cellular mechanism of human 5-HT6 receptor through an interaction with FynPSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2AGlutamatergic substrates of drug addiction and alcoholismGlucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injuryNeuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.Regulation of NMDA receptors by the tyrosine kinase FynFyn-dependent gene networks in acute ethanol sensitivityThe effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domainsInteraction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducinAlcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's diseasePrion protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate receptor (NMDAR) activityRoles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functionsDepolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slicesScaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol.Synaptic effects induced by alcohol.Decreased sensitivity of NMDA receptors on dopaminergic neurons from the posterior ventral tegmental area following chronic nondependent alcohol consumptionRegulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal.Fyn tyrosine kinase regulates oligodendroglial cell development but is not required for morphological differentiation of oligodendrocytes.Possible involvement of Fyn kinase in ethanol-stimulated Cas tyrosine phosphorylation in rat cerebellum and cerebral cortex.Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats.Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward.Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturationStructural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity.Acute effects of ethanol on glutamate receptors.Signaling cascades regulating NMDA receptor sensitivity to ethanol.The neurobiology of alcohol consumption and alcoholism: an integrative historyFyn is required for haloperidol-induced catalepsy in mice.Protein kinases and addiction.Ethanol acutely inhibits ionotropic glutamate receptor-mediated responses and long-term potentiation in the developing CA1 hippocampus.Inhibition by ethanol of NMDA-induced responses and acute tolerance to the inhibition in rat sympathetic preganglionic neurons in vitro and in vivo.Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner.Candidate genes for alcohol dependence: animal studies.Functional adaptation of the N-methyl-D-aspartate receptor to inhibition by ethanol is modulated by striatal-enriched protein tyrosine phosphatase and p38 mitogen-activated protein kinase.Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase αActin depolymerization contributes to ethanol inhibition of NMDA receptors in primary cultured cerebellar granule cells.Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disordersGene expression in animals with different acute responses to ethanol.
P2860
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P2860
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
description
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1997
@ast
im Oktober 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/10/24)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/10/24)
@nl
наукова стаття, опублікована в жовтні 1997
@uk
name
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@ast
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@en
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@nl
type
label
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@ast
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@en
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@nl
prefLabel
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@ast
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@en
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@nl
P2093
P3181
P1433
P1476
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
@en
P2093
H. Kitazawa
T. Miyakawa
P304
P3181
P356
10.1126/SCIENCE.278.5338.698
P407
P577
1997-10-24T00:00:00Z