Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. - Wikidata - wikimedia - TriplyDB

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.

http://www.wikidata.org/entity/Q33722964

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Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system Diverse impact of acute and long-term extracellular proteolytic activity on plasticity of neuronal excitability Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation.Key role of tissue plasminogen activator in neurovascular coupling Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.Ethanol effects on N-methyl-D-aspartate receptors in the bed nucleus of the stria terminalis.Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis.Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.Hemostasis and alterations of the central nervous system Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence.Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator Glucagon protects against impaired NMDA-mediated cerebrovasodilation and cerebral autoregulation during hypotension after brain injury by activating cAMP protein kinase A and inhibiting upregulation of tPA.Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice.Exogenous t-PA administration increases hippocampal mature BDNF levels. plasmin- or NMDA-dependent mechanism?Desmoteplase: discovery, insights and opportunities for ischaemic stroke.GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.Treatment of TBI with collagen scaffolds and human marrow stromal cells increases the expression of tissue plasminogen activator.Identification of a neurovascular signaling pathway regulating seizures in mice Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system.Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor.A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator.Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders.Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13 Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors.Review. Neurogenetic studies of alcohol addiction.Alcohol related changes in regulation of NMDA receptor functions Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.tPA-S(481)A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1.A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta.Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex.Plasminogen activation and thrombolysis for ischemic stroke.Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder.Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.

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Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.

http://www.wikidata.org/entity/Q33722964

description

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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name

Ethanol-withdrawal seizures ar ...... R2B-containing NMDA receptors.

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Ethanol-withdrawal seizures ar ...... R2B-containing NMDA receptors.

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type

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Ethanol-withdrawal seizures ar ...... R2B-containing NMDA receptors.

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Ethanol-withdrawal seizures ar ...... R2B-containing NMDA receptors.

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Ethanol-withdrawal seizures ar ...... R2B-containing NMDA receptors.

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Ethanol-withdrawal seizures ar ...... R2B-containing NMDA receptors.

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Proceedings of the National Academy of Sciences of the United States of America

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Ethanol-withdrawal seizures ar ...... R2B-containing NMDA receptors.

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Anna E Skrzypiec

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Jerry P Melchor

http://www.w3.org/2001/XMLSchema#string

Robert Pawlak

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Sidney Strickland

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Tomasz Matys

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P2860

Genetic enhancement of learning and memory in mice

The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function

Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

Endothelial cell fibrinolysis: transcriptional regulation of fibrinolytic protein gene expression (t-PA, u-PA, and PAI-1) by low alcohol.

The plasminogen (fibrinolytic) system.

Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice.

Extracellular proteolysis in the adult murine brain

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2

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102

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15630096

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544297

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