Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene
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Repression of myelin proteolipid protein gene expression is mediated through both general and cell type-specific negative regulatory elements in nonexpressing cellsLamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model.Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice.Different proteolipid protein mutants exhibit unique metabolic defects.Distinct phenotypes associated with increasing dosage of the PLP gene: implications for CMT1A due to PMP22 gene duplication.High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology.Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brainAxon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease.The effect of myelinating Schwann cells on axons.Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelinationCNS myelination and PLP gene dosage.Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouseRole of immune cells in animal models for inherited neuropathies: facts and visions.Insertion of mutant proteolipid protein results in missorting of myelin proteins.T-cell-mediated disruption of the neuronal microtubule network: correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis.Metachromatic leukodystrophy: recent research developments.Modeling the natural history of Pelizaeus-Merzbacher disease.Insertion of proteolipid protein into oligodendrocyte mitochondria regulates extracellular pH and adenosine triphosphateGait abnormalities and progressive myelin degeneration in a new murine model of Pelizaeus-Merzbacher disease with tandem genomic duplication.CD4 T cells: Balancing the coming and going of autoimmune-mediated inflammation in the CNS.Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models.Neuronal loss in Pelizaeus-Merzbacher disease differs in various mutations of the proteolipid protein 1.Neuroprotective effect of oligodendrocyte precursor cell transplantation in a long-term model of periventricular leukomalaciaProgesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model.Critical appraisal of animal models of multiple sclerosis.Neuroinflammation as modifier of genetically caused neurological disorders of the central nervous system: Understanding pathogenesis and chances for treatment.Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders.Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.Myelin proteolipid protein, basic protein, the small isoform of myelin-associated glycoprotein, and p42MAPK are associated in the Triton X-100 extract of central nervous system myelin.Current concepts of PLP and its role in the nervous system.Distal axonopathy in peripheral nerves of PMP22-mutant mice.Time-course of myelination and atrophy on cerebral imaging in 35 patients with PLP1-related disorders.Mouse models of myelin diseases.A PLP splicing abnormality is associated with an unusual presentation of PMD.Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey.Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched dietCell Densities in the Mouse Brain: A Systematic Review
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P2860
Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene
description
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im Mai 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/05/18)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/05/18)
@nl
наукова стаття, опублікована в травні 1998
@uk
научни чланак (објављен 1998/05/18)
@sr
name
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@ast
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@en
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@nl
type
label
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@ast
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@en
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@nl
prefLabel
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@ast
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@en
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@nl
P2093
P2860
P1476
Late-onset neurodegeneration i ...... f the proteolipid protein gene
@en
P2093
A. Schneider
D. Kirkham
E. Kyriakides
I. R. Griffiths
J. A. Barrie
K. A. Nave
M. C. McCulloch
M. Klugmann
T. J. Anderson
P2860
P304
P356
10.1002/(SICI)1096-9861(19980518)394:4<506::AID-CNE8>3.0.CO;2-5
P407
P577
1998-05-18T00:00:00Z