The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesSRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactomeC-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptorInteraction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domainsRole of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptorCross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic signaling in adipocytesFyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated ProteinsIdentification of Grb10 as a direct substrate for members of the Src tyrosine kinase familySustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesisInsulin receptor substrate 4 associates with the protein IRAS14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domainFunctional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptorsInsulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinaseSodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal controlFyn tyrosine kinase regulates oligodendroglial cell development but is not required for morphological differentiation of oligodendrocytes.Regulation of mucin MUC2 gene expression during colon carcinogenesis.Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistanceYES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cellsDeficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA.Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistancepp60Src mediates insulin-stimulated sequestration of the beta(2)-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activation.A rare co-segregation-mutation in the insulin receptor substrate 1 gene in one Chinese family with ankylosing spondylitisIRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation.The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling moleculesSpecific protein kinase C isoforms as transducers and modulators of insulin signalingYMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites.Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation.Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.Nuclear IRS-1 and cancerPhytochemical regulation of Fyn and AMPK signaling circuitry.Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes.Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion.Differentiation and mineralization of murine mesenchymal C3H10T1/2 cells in micromass culture.c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway.Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3-kinase signalling.
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P2860
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation
description
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im Mai 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/05/03)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/05/03)
@nl
наукова стаття, опублікована в травні 1996
@uk
name
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@ast
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@en
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@nl
type
label
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@ast
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@en
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@nl
prefLabel
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@ast
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@en
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@nl
P2093
P2860
P356
P1476
The Fyn tyrosine kinase binds ...... lex during insulin stimulation
@en
P2093
P2860
P304
10583-10587
P356
10.1074/JBC.271.18.10583
P407
P577
1996-05-01T00:00:00Z