deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes - Wikidata - wikimedia - TriplyDB

deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes

deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes

http://www.wikidata.org/entity/Q28510655

about

Dlx genes, p63, and ectodermal dysplasias.p63 regulates proliferation and differentiation of developmentally mature keratinocytes p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation p63 is the molecular switch for initiation of an epithelial stratification program Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice Dysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytes Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Transcription factor p63 regulates key genes and wound repair in human airway epithelial basal cells Transcriptional control of epidermal specification and differentiation.RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability.ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2.C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells.Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure.Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation.DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage DeltaNp63alpha confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.p63 regulates olfactory stem cell self-renewal and differentiation.p63 induces key target genes required for epidermal morphogenesis.The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers ΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion.Transcription factor p63 controls the reserve status but not the stemness of horizontal basal cells in the olfactory epithelium.UBE4B: a promising regulatory molecule in neuronal death and survival.Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63 Notch tumor suppressor function ΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis A symphony of regulations centered on p63 to control development of ectoderm-derived structures.Dysregulated ΔNp63α negatively regulates the maspin promoter in keratinocytes via blocking endogenous p73 binding.Differential recognition of response elements determines target gene specificity for p53 and p63 p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch.New p63 targets in keratinocytes identified by a genome-wide approach.Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63.

P2860

Q24535426-63CA5560-55E6-4E0E-B33F-0C7C607FDBB3 Q24675193-86EFE9C4-4DA1-4C66-A6FA-F95C90A43DCC Q27318144-76ACB6C6-8248-4A6F-BE93-13B1F923615D Q28507173-1E8EF985-34F8-4275-99C8-257EE74AF268 Q28510156-F812D69C-E829-416F-96F9-FF9954BFB4F7 Q28512876-18290304-90F2-42D4-AABC-CD7856C42217 Q28589270-10A908B9-1A41-43F4-856C-08FFE9182B51 Q28742570-9FD6D9EB-B3CF-44FC-BA23-EEF3A1C0EB5F Q33285551-457CDCCE-1CFC-4DB5-AB7F-C60DB26FE687 Q33358710-7EAFF1B6-07EF-445D-97C9-9341C8BC6CAA Q33765080-4F9D34C7-FCAF-4B64-8529-FE04CF21307B Q33946157-8B461587-901A-4506-930C-119E244B988F Q34006360-4FD11887-B3FD-46E9-9177-7DEC91CF0285 Q34017928-16D07617-331E-4A6A-9566-1C2465B6516B Q34022559-104A5D62-DE2F-46BF-AEC8-40ACAEEABB9B Q34131395-B7FF84C6-5A21-40F4-BFD5-2BAF042CAB9E Q34231282-21AB0AF3-9486-487E-9059-A4B38CD41067 Q34399666-F54F879A-96A3-4D91-A693-45746D9EF8A1 Q34752036-653D29AC-DA05-47F7-8544-8BBC94280D4D Q34753639-A4C3E02B-5725-4C1D-B87E-7C57CB897CA4 Q34795259-ABCD396D-F7AB-41EC-B094-C5DA651C85DD Q35098103-1EB86415-BDC1-41C5-9F60-AE610C5347F2 Q35288642-876B731A-EB1A-4609-92FB-8C8C49DB4818 Q35619218-678ABA17-51C0-45BC-8978-248BC9BF1A38 Q35652182-8A6F6D0A-267A-4368-8661-BFA3AD8EB275 Q35745252-1B196647-39AF-4DAF-9AF8-B279DD6481D7 Q35897788-93E9453D-BE6E-4833-89FE-F2008818B03E Q36056704-7164B5AF-B306-4E94-9F72-D31E2D5562A1 Q36538525-F62D0A35-B2D5-4CBC-B29F-8DEC4A3D93E1 Q36700199-39703FC5-37BF-4A58-A2F5-50F0FF5EAA33 Q37142886-CACC544D-4AD3-4D1E-BCFC-A657DF2543A3 Q37256446-2222BA46-7779-4078-A44C-31FE281ACD60 Q37631111-3F454657-38D8-4F85-AF2D-D0A51CA0A1FF Q37895920-0ED31EC5-B0F2-4296-B892-1192C3D1866F Q38317198-4AACBDA6-F441-4880-91F6-B20D888D3856 Q38324246-4C20F062-B2AE-4CCE-BF83-D3C1FEFDFCC3 Q38445346-B81E0EDB-D163-4BE0-BE1D-BA4954447B40 Q38789949-8830FD20-BD19-44B4-84C1-11DDD48A0A88 Q38977591-B0BCE1C3-F84A-43D5-8295-DC8C21701394 Q39227140-3D6D716D-4A8D-4C5C-A63F-CF44F9355C91

P2860

deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes

http://www.wikidata.org/entity/Q28510655

description

2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունիսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2003

@ast

im Juni 2003 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2003/06/05)

@sk

vědecký článek publikovaný v roce 2003

@cs

wetenschappelijk artikel (gepubliceerd op 2003/06/05)

@nl

наукова стаття, опублікована в червні 2003

@uk

مقالة علمية (نشرت في 5-6-2003)

@ar

name

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@ast

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@en

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@nl

type

label

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@ast

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@en

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@nl

prefLabel

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@ast

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@en

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@nl

P1433

Q28510655-91195094-F1DC-47BD-B8C9-FD30BF8D8F4E

P1476

Q28510655-C6D397F8-6B94-478E-9C51-D9FF6C36D142

P2093

Q28510655-26F2B796-CC76-4AC3-9A20-37F43C91C957

Q28510655-4C99B968-B069-4A45-AC97-14194B9F3959

Q28510655-6C99035F-3A23-4E98-B3B4-2FA42E95EC9A

Q28510655-9B80A987-973E-489F-B8CC-4F26590E7992

Q28510655-ADF9EED0-7DF1-4FB6-9960-7144AEAF8628

Q28510655-D51683D0-C171-4917-92E2-89B8A5340D22

Q28510655-DE25CB43-9EAB-4094-B198-FD06FB71F985

P2860

Q28510655-21487BE3-DF10-4BC6-A3B2-E7BEC59BDF10

Q28510655-2BF3E951-8389-4C7D-8A53-4D5F7EA15685

Q28510655-39A9B14D-FCBA-4647-965F-E5F7203141ED

Q28510655-3BCC7F5D-24F4-4C06-AC63-253090C1EBA4

Q28510655-4595498C-E21F-452F-9BCD-06C00E38CC84

Q28510655-52A99273-CF59-4CD3-AADC-1078F41DB109

Q28510655-593A3135-3129-495A-9B28-F031C835AF64

Q28510655-70315079-CB41-490B-9F30-D6F8758C13E3

Q28510655-73609958-5E53-49D6-9DF8-191FEB2A81BD

Q28510655-837037C5-9538-473E-A659-272087E78962

P2888

Q28510655-12534393-4092-44F7-91AF-06E2ABBE6180

P304

Q28510655-0DC265AF-AD3B-4CD0-AF8D-4610E99969C2

P31

Q28510655-B706A280-25B6-476F-A567-692F9A90681F

P356

Q28510655-2EC7DF28-4708-4303-A38C-B184A36674DB

P407

Q28510655-BF3C7565-65FB-4582-95F4-CEDD3345919B

P433

Q28510655-2DAE7373-E70D-4B8D-B064-38F9AADD8AC2

P478

Q28510655-7F584929-0552-4339-B951-45A5F29EFDF0

P577

Q28510655-D9879F1E-23AE-45A1-9075-8F69ABDB0BC9

P6179

Q28510655-8942A9E1-2968-4140-9AEF-3B5AB54A5C06

P698

Q28510655-DE9145D0-949D-43ED-B9C6-50B6503DB5B1

P356

P1433

P1476

deltaNp63alpha functions as bo ...... iation of murine keratinocytes

@en

P2093

Kathryn E. King

http://www.w3.org/2001/XMLSchema#string

Lela A. Lee

http://www.w3.org/2001/XMLSchema#string

Marian F. Young

http://www.w3.org/2001/XMLSchema#string

Roshini M. Ponnamperuma

http://www.w3.org/2001/XMLSchema#string

Takashi Tokino

http://www.w3.org/2001/XMLSchema#string

Toshiharu Yamashita

http://www.w3.org/2001/XMLSchema#string

Wendy C. Weinberg

http://www.w3.org/2001/XMLSchema#string

P2860

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51

p53 associates with and targets Delta Np63 into a protein degradation pathway

P63 and P73: P53 mimics, menaces and more.

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

AIS is an oncogene amplified in squamous cell carcinoma.

p63 and p73 transactivate differentiation gene promoters in human keratinocytes.

Association of p63 with proliferative potential in normal and neoplastic human keratinocytes.

CUSP/p63 expression in rat and human tissues.

P2888

P304

3635–3644

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.ONC.1206536

http://www.w3.org/2001/XMLSchema#string

P407

P433

23

http://www.w3.org/2001/XMLSchema#string

P478

22

http://www.w3.org/2001/XMLSchema#string

P577

2003-06-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P6179

1006589554

http://www.w3.org/2001/XMLSchema#string

P698

12789272

http://www.w3.org/2001/XMLSchema#string