p53 associates with and targets Delta Np63 into a protein degradation pathway - Wikidata - wikimedia - TriplyDB

p53 associates with and targets Delta Np63 into a protein degradation pathway

p53 associates with and targets Delta Np63 into a protein degradation pathway

http://www.wikidata.org/entity/Q34106545

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A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.Dlx genes, p63, and ectodermal dysplasias.P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescence p63 deficiency activates a program of cellular senescence and leads to accelerated aging Regulation of p63 protein stability via ubiquitin-proteasome pathway.C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells.Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta Assessing TP53 status in human tumours to evaluate clinical outcome.ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations Chronic ulcerative stomatitis.Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings.Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.Impaired delta NP63 expression is associated with poor tumor development in transitional cell carcinoma of the bladder Upregulation of cell adhesion through delta Np63 silencing in human 5637 bladder cancer cells.How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.Impaired Delta Np63 expression associates with reduced beta-catenin and aggressive phenotypes of urothelial neoplasms ASK1/JNK-mediated TAp63 activation controls the cell survival signal of baicalein-treated EBV-transformed B cells.Association of differential β-catenin expression with Oct-4 and Nanog in oral squamous cell carcinoma and their correlation with clinicopathological factors and prognosis.DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations.Decreased TAp63 and ΔNp63 mRNA Levels in Most Human Pituitary Adenomas Are Correlated with Notch3/Jagged1 Relative Expression.Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?Aberrant expression of β-catenin and its association with ΔNp63, Notch-1, and clinicopathological factors in oral squamous cell carcinoma.Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of ΔNp63.Regulation of DeltaNp63alpha by tumor necrosis factor-alpha in epithelial homeostasis.Cytoplasmic localization of p63 is associated with poor patient survival in lung adenocarcinoma.Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63.Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation.Abnormal cell proliferation in the p75NTR-positive basal cell compartment of the esophageal epithelium during squamous carcinogenesis.Expression of p63 protein and mRNA in oral epithelial dysplasia.Autoimmunity to deltaNp63alpha in chronic ulcerative stomatitis.High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.Immunohistochemical expression of p63 and deltaNp63 in mixed tumors of canine mammary glands and its relation with p53 expression.

P2860

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P2860

p53 associates with and targets Delta Np63 into a protein degradation pathway

http://www.wikidata.org/entity/Q34106545

description

2001 nî lūn-bûn

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2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի փետրվարին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

p53 associates with and targets Delta Np63 into a protein degradation pathway

@ast

p53 associates with and targets Delta Np63 into a protein degradation pathway

@en

p53 associates with and targets Delta Np63 into a protein degradation pathway

@nl

type

label

p53 associates with and targets Delta Np63 into a protein degradation pathway

@ast

p53 associates with and targets Delta Np63 into a protein degradation pathway

@en

p53 associates with and targets Delta Np63 into a protein degradation pathway

@nl

prefLabel

p53 associates with and targets Delta Np63 into a protein degradation pathway

@ast

p53 associates with and targets Delta Np63 into a protein degradation pathway

@en

p53 associates with and targets Delta Np63 into a protein degradation pathway

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Proceedings of the National Academy of Sciences of the United States of America

P1476

p53 associates with and targets Delta Np63 into a protein degradation pathway

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P2093

B Trink

http://www.w3.org/2001/XMLSchema#string

D Sidransky

http://www.w3.org/2001/XMLSchema#string

E A Ratovitski

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K Hibi

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K Yamaguchi

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M Patturajan

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P2860

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

A model for p53-induced apoptosis

A new human p53 homologue

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

Mdm2 promotes the rapid degradation of p53

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

Oncogenic forms of p53 inhibit p53-regulated gene expression

P304

1817-1822

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4

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12158406

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11172034

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29340

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